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Literature summary for 3.4.22.53 extracted from

  • Su, Y.; Cui, Z.; Li, Z.; Bloc, E.R.
    Calpain-2 regulation of VEGF-mediated angiogenesis (2006), FASEB J., 20, 1443-1451.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens calpain mediates angiogenic effects induced by vascular endothelial growth factor by modulating actin cytoskeletal organization ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell pulmonary microvascular endothelial cell. Incubation of the cells with vascular endothelial growth factor results in dose- and time-dependent increases in calpain activity and protein content of calpain-2. Vascular endothelial growth factor does not change the protein contents of calpain-1 and the small subunit or of calpastatin. Inhibition of calpain activity by siRNA directed against calpain-2 and by overexpression of calpastatin prevents vascular endothelial growth factor-induced increases in actin stress fibers in endothelial cells and angiogenesis Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information calpain mediates angiogenic effects induced by vascular endothelial growth factor by modulating actin cytoskeletal organization Homo sapiens ?
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