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Literature summary for 3.4.22.53 extracted from

  • Han, Y.; Weinman, S.; Boldogh, I.; Walker, R.K.; Brasier, A.R.
    Tumor necrosis factor-a-inducible I.kappa.Ba proteolysis mediated by cytosolic m-calpain. A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kB activation (1999), J. Biol. Chem., 274, 787-794.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
TNF-alpha activates cytosolic enzyme Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-Leu-Leu-leucinal
-
Oryctolagus cuniculus
benzyloxycarbonyl-Leu-Leu-phenylalaninal
-
Oryctolagus cuniculus
benzyloxycarbonyl-Leu-Leu-Tyr diazomethyl ketone
-
Oryctolagus cuniculus
benzyloxycarbonyl-Leu-norleucinal
-
Oryctolagus cuniculus
E-64 i.e. trans-epoxysuccinyl-L-leucylamido-(4-guanido)butane Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Oryctolagus cuniculus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
IkappaBalpha + H2O Oryctolagus cuniculus a parallel pathway that degrades IkappaBalpha and activates NF-kappaB activation independently of the ubiquitin-proteasome pathway ?
-
?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Boc-Leu-Met-7-amino-4-chloromethylcoumarin
-
Oryctolagus cuniculus ?
-
?
casein + H2O
-
Oryctolagus cuniculus ?
-
?
IkappaBalpha + H2O
-
Oryctolagus cuniculus ?
-
?
IkappaBalpha + H2O a parallel pathway that degrades IkappaBalpha and activates NF-kappaB activation independently of the ubiquitin-proteasome pathway Oryctolagus cuniculus ?
-
?