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Literature summary for 3.4.22.52 extracted from

  • Ni, R.; Zheng, D.; Xiong, S.; Hill, D.J.; Sun, T.; Gardiner, R.B.; Fan, G.C.; Lu, Y.; Abel, E.D.; Greer, P.A.; Peng, T.
    Mitochondrial calpain-1 disrupts ATP synthase and induces superoxide generation in type 1 diabetic hearts a novel mechanism contributing to diabetic cardiomyopathy (2016), Diabetes, 65, 255-268 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.52

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP synthase-alpha (ATP5A1) + H2O Mus musculus calpain-1 accumulation in mitochondria disrupts ATP synthase and induces ROS generation, which promotes diabetic cardiomyopathy ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus O35350 catalytic subunit
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP synthase-alpha (ATP5A1) + H2O
-
 Mus musculus ?
-
 ?
ATP synthase-alpha (ATP5A1) + H2O calpain-1 accumulation in mitochondria disrupts ATP synthase and induces ROS generation, which promotes diabetic cardiomyopathy Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
calpain-1
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus calpain-1 protein and activity in mitochondria are elevated in diabetic mouse hearts up

General Information

General Information Comment Organism
physiological function calpain-1 accumulation in mitochondria disrupts ATP synthase and induces ROS generation, which promotes diabetic cardiomyopathy Mus musculus