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Literature summary for 3.4.22.52 extracted from

  • Chen, Q.; Lesnefsky, E.J.
    Heart mitochondria and calpain 1 Location, function, and targets (2015), Biochim. Biophys. Acta, 1852, 2372-2378 .
    View publication on PubMed
Search for more literature for 3.4.22.52

Application

Application Comment Organism
medicine inhibition of the mitochondrial calpain 1 could be a potential strategy to decrease cardiac injury during ischemia-reperfusion Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion mitochondrial calpain 1 is located within the intermembrane space and mitochondrial matrix Homo sapiens 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
apoptosis inducing factor + H2O Homo sapiens activated mitochondrial calpain 1 within intermembrane space cleaves apoptosis inducing factor (AIF), whereas the activated mitochondrial calpain 1 within the matrix cleaves complex I subunits and metabolic enzymes ?
-
 ?
complex I subunits + H2O Homo sapiens activated mitochondrial calpain 1 within intermembrane space cleaves apoptosis inducing factor (AIF), whereas the activated mitochondrial calpain 1 within the matrix cleaves complex I subunits and metabolic enzymes ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P07384
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
apoptosis inducing factor + H2O
-
 Homo sapiens ?
-
 ?
apoptosis inducing factor + H2O activated mitochondrial calpain 1 within intermembrane space cleaves apoptosis inducing factor (AIF), whereas the activated mitochondrial calpain 1 within the matrix cleaves complex I subunits and metabolic enzymes Homo sapiens ?
-
 ?
complex I subunits + H2O
-
 Homo sapiens ?
-
 ?
complex I subunits + H2O activated mitochondrial calpain 1 within intermembrane space cleaves apoptosis inducing factor (AIF), whereas the activated mitochondrial calpain 1 within the matrix cleaves complex I subunits and metabolic enzymes Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
mit-CPN1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function activated mitochondrial calpain 1 within intermembrane space cleaves apoptosis inducing factor (AIF), whereas the activated mitochondrial calpain 1 within the matrix cleaves complex I subunits and metabolic enzymes Homo sapiens