Literature summary for 3.4.22.52 extracted from

  • Van Ba, H.; Inho, H.
    Significant role of mu-calpain (CANP1) in proliferation/survival of bovine skeletal muscle satellite cells (2013), In Vitro Cell. Dev. Biol. Anim., 49, 785-797.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle satellite cell
-
Bos taurus
-

Synonyms

Synonyms Comment Organism
mu-calpain
-
Bos taurus
CANP1
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Bos taurus

General Information

General Information Comment Organism
physiological function the enzyme plays key roles in regulation of cell proliferation and survival of of bovine skeletal satellite cells Bos taurus
malfunction suppression of calpain 1 significantly reduces cell viability in cell proliferation when compared with control cells. Suppression of calpain 1 results in an increase in the expressions of apoptotic caspases such as caspase-3, caspase-6, caspase-7, caspase-8, and caspase-9, as well as heat-shock protein systems and leads to the upregulation of other apoptosis and DNA damage-regulating genes whilst at the same time downregulating proliferation, migration, and differentiation-regulating genes Bos taurus