Literature summary for 3.4.22.52 extracted from

  • Bastian, Y.; Roa-Espitia, A.; Mujica, A.; Hernandez-Gonzalez, E.
    Calpain modulates capacitation and acrosome reaction through cleavage of the spectrin cytoskeleton (2010), Reproduction, 140, 673-684.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
calpeptin complete inhibition at 0.5 mM Cavia porcellus
N-acetyl-Leu-Leu-Nle-CHO complete inhibition at 0.5 mM Cavia porcellus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm calpain-1 is relocated and translocated from cytoplasm to plasma membrane during capacitation Cavia porcellus
-
-
plasma membrane calpain-1 is relocated and translocated from cytoplasm to plasma membrane during capacitation Cavia porcellus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Cavia porcellus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
x * 80000, SDS-PAGE Cavia porcellus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
spectrin + H2O Cavia porcellus
-
?
-
?
filamin-1 + H2O Cavia porcellus
-
?
-
?
utrophin + H2O Cavia porcellus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
sperm
-
Cavia porcellus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
spectrin + H2O
-
Cavia porcellus ?
-
?
filamin-1 + H2O
-
Cavia porcellus ?
-
?
utrophin + H2O
-
Cavia porcellus ?
-
?

Subunits

Subunits Comment Organism
? x * 80000, SDS-PAGE Cavia porcellus

General Information

General Information Comment Organism
physiological function calpain-1 inhibits the acrosome reaction and alters the plasma membrane-associated cytoskeleton in spermatozoa Cavia porcellus