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Literature summary for 3.4.22.52 extracted from

  • Panigrahi, A.K.; Zhang, N.; Mao, Q.; Pati, D.
    Calpain-1 cleaves Rad21 to promote sister chromatid separation (2011), Mol. Cell. Biol., 31, 4335-4347.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus calpain-1 normally localizes to the interphase nuclei and chromatin Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Rad21 + H2O Homo sapiens calpain-1 cleaves Rad21 at Leu192 ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
Homo sapiens
-
MOLT-4 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Rad21 + H2O calpain-1 cleaves Rad21 at Leu192 Homo sapiens ?
-
?

General Information

General Information Comment Organism
malfunction engineered cleavage of Rad21 at the calpain-cleavable site without activation of calpain-1 can lead to a loss of sister chromatid cohesion Homo sapiens
physiological function Rad21 cleavage by calpain-1 promotes separation of sister chromatid arms Homo sapiens