Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | calpain-1 normally localizes to the interphase nuclei and chromatin | Homo sapiens | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Rad21 + H2O | Homo sapiens | calpain-1 cleaves Rad21 at Leu192 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
JURKAT cell | - |
Homo sapiens | - |
MOLT-4 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Rad21 + H2O | calpain-1 cleaves Rad21 at Leu192 | Homo sapiens | ? | - |
? |
General Information | Comment | Organism |
---|---|---|
malfunction | engineered cleavage of Rad21 at the calpain-cleavable site without activation of calpain-1 can lead to a loss of sister chromatid cohesion | Homo sapiens |
physiological function | Rad21 cleavage by calpain-1 promotes separation of sister chromatid arms | Homo sapiens |