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Literature summary for 3.4.22.52 extracted from

  • Chen, Q.; Paillard, M.; Gomez, L.; Ross, T.; Hu, Y.; Xu, A.; Lesnefsky, E.J.
    Activation of mitochondrial mu-calpain increases AIF cleavage in cardiac mitochondria during ischemia-reperfusion (2011), Biochem. Biophys. Res. Commun., 415, 533-538.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
MDL-28170
-
Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion present mostly in the intermembrane space Mus musculus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activation of mu-calpain requires micromolar calcium (0.4 mM used in assays) Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
apoptosis inducing factor + H2O Mus musculus
-
truncated apoptosis inducing factor + ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
apoptosis inducing factor + H2O
-
Mus musculus truncated apoptosis inducing factor + ?
-
?
succinyl-L-Leu-L-Tyr-7-amido-4-methylcoumarin + H2O
-
Mus musculus succinyl-L-Leu-L-Tyr + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
calpain I
-
Mus musculus
mito-mu-calpain
-
Mus musculus
mu-calpain
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus mitochondrial mu-calpain activity is increased by 160% during ischemia-reperfusion compared to time control up

General Information

General Information Comment Organism
physiological function exogenous calcium treatment induces a calpain-dependent decrease of mitochondrial apoptosis inducing factor content in isolated mouse heart mitochondria Mus musculus