Literature summary for 3.4.22.52 extracted from

Hamelet, J.; Couty, J.P.; Crain, A.M.; Noll, C.; Postic, C.; Paul, J.L.; Delabar, J.M.; Viguier, M.; Janel, N.
Calpain activation is required for homocysteine-mediated hepatic degradation of inhibitor Ikappa B alpha (2009), Mol. Genet. Metab., 97, 114-120.

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Inhibitors

Inhibitors	Comment	Organism	Structure
calpain inhibitor-1	-	Mus musculus
calpastatin	-	Mus musculus
MG132	-	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocyte	-	Mus musculus	-
Kupffer cell	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-succinyl-Leu-Tyr-7-amido-4-methylcoumarin + H2O	-	Mus musculus	N-succinyl-Leu-Tyr + 7-amino-4-methylcoumarin	-	?

Synonyms

Synonyms	Comment	Organism
calpain 1	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	calpain activity in liver of heterozygous cystathionine beta synthase-deficient mice shows a 30% increase compared to wild type mice	up

General Information

General Information	Comment	Organism
physiological function	calpain activation is required for homocysteine-mediated hepatic degradation of inhibitor Ikappa B alpha	Mus musculus

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Release 2023.1 (January 2023)