Literature summary for 3.4.22.52 extracted from

  • Hamelet, J.; Couty, J.P.; Crain, A.M.; Noll, C.; Postic, C.; Paul, J.L.; Delabar, J.M.; Viguier, M.; Janel, N.
    Calpain activation is required for homocysteine-mediated hepatic degradation of inhibitor Ikappa B alpha (2009), Mol. Genet. Metab., 97, 114-120.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
calpain inhibitor-1
-
Mus musculus
calpastatin
-
Mus musculus
MG132
-
Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Mus musculus
-
Kupffer cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-succinyl-Leu-Tyr-7-amido-4-methylcoumarin + H2O
-
Mus musculus N-succinyl-Leu-Tyr + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
calpain 1
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus calpain activity in liver of heterozygous cystathionine beta synthase-deficient mice shows a 30% increase compared to wild type mice up

General Information

General Information Comment Organism
physiological function calpain activation is required for homocysteine-mediated hepatic degradation of inhibitor Ikappa B alpha Mus musculus