Literature summary for 3.4.22.52 extracted from

  • Simonin, Y.; Disson, O.; Lerat, H.; Antoine, E.; Biname, F.; Rosenberg, A.R.; Desagher, S.; Lassus, P.; Bioulac-Sage, P.; Hibner, U.
    Calpain activation by hepatitis C virus proteins inhibits the extrinsic apoptotic signaling pathway (2009), Hepatology, 50, 1370-1379.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
NS5A protein the nonstructural hepatitis C virus protein NS5Ais sufficient to activate a calpain 1 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
E64d
-
Homo sapiens
MDL-28170
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Huh-7 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
BH3-only Bcl2 interacting domain + H2O BH3-only Bcl2 interacting domain is a direct target of a soluble active calpain 1 present in cells expressing hepatitis C virus proteins Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
calpain 1
-
Homo sapiens