Literature summary for 3.4.22.52 extracted from

  • Pietsch, M.; Chua, K.C.; Abell, A.D.
    Calpains: attractive targets for the development of synthetic inhibitors (2010), Curr. Top. Med. Chem., 10, 270-293.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-(2-chloro-4-hydroxyphenyl)-4-oxo-7-(pyridin-4-yl)-1,4-dihydroquinoline-3-carboxamide
-
Homo sapiens
1-[(4-methylphenyl)sulfonyl]-N-(1-oxo-3-phenylpropan-2-yl)-D-prolinamide
-
Homo sapiens
2-methyl-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-7,8-dihydro-2H-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxamide 1,1-dioxide
-
Homo sapiens
(2S)-2-[[(4-fluorophenyl)sulfonyl]amino]-N-[(3S)-2-hydroxytetrahydrofuran-3-yl]-3-methylbutanamide
-
Homo sapiens
(2S,5S)-5-benzyl-6-hydroxy-2-(2-methylpropyl)morpholin-3-one SNJ-1757 Homo sapiens
3-([4-[2-(methoxymethoxy)phenyl]-4-oxobutanoyl]amino)-2-oxo-4-phenylbutanamide reversible inhibitor Homo sapiens
3-acetyl-8-chloro-2-[(2,4-dibromophenyl)amino]-5-methylquinolin-4(1H)-one
-
Homo sapiens
3-([N-[(benzyloxy)carbonyl]-L-leucyl]amino)-2-oxo-4-phenylbutanoic acid reversible inhibitor Homo sapiens
(3S)-2-hydroxytetrahydrofuran-3-yl N-[(10H-phenothiazin-2-yloxy)acetyl]-L-threonyl-L-leucinate
-
Homo sapiens
(3S)-2-hydroxytetrahydrofuran-3-yl N-[(2S)-2-[[(10H-phenothiazin-2-yloxy)acetyl]amino]butanoyl]-L-leucinate
-
Homo sapiens
(3S)-3-[[N-(10H-phenothiazin-2-ylcarbonyl)-L-norvalyl]amino]tetrahydrofuran-2-yl acetate BN-82270 Homo sapiens
4-(4-bromophenyl)-3-([N-[5-(1,2-dithiolan-3-yl)pentanoyl]-L-leucyl]amino)-2-oxobutanoic acid reversible inhibitor Homo sapiens
(4S)-3-[(4-methylphenyl)sulfonyl]-N-(1-oxo-3-phenylpropan-2-yl)-1,3-thiazolidine-4-carboxamide
-
Homo sapiens
5-azanylidyne-N-[[(2S,3S)-3-(ethoxycarbonyl)oxiran-2-yl]carbonyl]-L-norvalyl-L-arginyl-L-tryptophanamide irreversible inhibitor Homo sapiens
5-formyl-N-[(2S)-3-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxobutan-2-yl]-1H-pyrrole-2-carboxamide CAT0059 Homo sapiens
5-formyl-N-[(2S)-3-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxobutan-2-yl]furan-2-carboxamide
-
Homo sapiens
5-formyl-N-[(2S)-3-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxobutan-2-yl]thiophene-2-carboxamide
-
Homo sapiens
(7S,10S,13S,26S)-13,26-dibenzyl-7-methyl-10-(propan-2-yl)-5,7,8,10,11,13,14,25,26,28-decahydrotetrabenzo[k,m,t,v][1,4,7,10,15,18]hexaazacyclotetracosine-6,9,12,15,24,27-hexone
-
Homo sapiens
acetyl-DPMSSTYIEE-betaAla-GKREVTIPPKYRELLA-NH2
-
Homo sapiens
acetyl-DPMSSTYIEELGKREVT-betaAla-PPKYRELLA-NH2
-
Homo sapiens
acetyl-DPMSSTYIEELGKREVTIPPKYRELLA-NH2 CP1B peptide Homo sapiens
acetyl-RRMKWKKDPMSSTYIEELGKREVTIPPKYRELLA-NH2
-
Homo sapiens
acetyl-SSTTYIEELGKREVTIPPKYR-NH2
-
Homo sapiens
acetyl-TYIEELGKREVTIPPKYR-NH2
-
Homo sapiens
AK-275 reversible inhibitor Homo sapiens
AK-295 reversible inhibitor Homo sapiens
AK-295-D1 reversible inhibitor Homo sapiens
AK-295-D2 reversible inhibitor Homo sapiens
ALLM reversible inhibitor Homo sapiens
ALLN reversible inhibitor Homo sapiens
benzyl [(6S,9S,12S)-6-formyl-9-(2-methylpropyl)-8,11-dioxo-2-oxa-7,10-diazabicyclo[12.2.2]octadeca-1(16),14,17-trien-12-yl]carbamate
-
Homo sapiens
benzyl [(7S,10S,13S)-7-formyl-10-(2-methylpropyl)-9,12-dioxo-2-oxa-8,11-diazabicyclo[13.2.2]nonadeca-1(17),15,18-trien-13-yl]carbamate CAT811 Homo sapiens
benzyl [(8S,11S,14S)-8-formyl-11-(2-methylpropyl)-10,13-dioxo-2-oxa-9,12-diazabicyclo[14.2.2]icosa-1(18),16,19-trien-14-yl]carbamate
-
Homo sapiens
calpastatin
-
Homo sapiens
calpeptin reversible inhibitor Homo sapiens
dimethyl (2S,2'S)-2,2'-[biphenyl-2,2'-diylbis(carbonylimino)]bis(3-phenylpropanoate)
-
Homo sapiens
E-64 irreversible inhibitor Homo sapiens
E-64c irreversible inhibitor Homo sapiens
E-64d irreversible inhibitor Homo sapiens
Ep-460 irreversible inhibitor Homo sapiens
(-)-epicatechin 5-gallate
-
Homo sapiens
ethyl 3-([N-[(benzyloxy)carbonyl]-L-leucyl]amino)-2-oxo-4-phenylbutanoate reversible inhibitor Homo sapiens
ethyl 4-(4-bromophenyl)-3-([N-[5-(1,2-dithiolan-3-yl)pentanoyl]-L-leucyl]amino)-2-oxobutanoate reversible inhibitor Homo sapiens
leupeptin reversible inhibitor Homo sapiens
MDL-28170 reversible inhibitor Homo sapiens
methyl N-[[2'-([(2S)-1-[(2'-aminobiphenyl-2-yl)amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl)biphenyl-2-yl]carbonyl]-L-phenylalanyl-L-valinate
-
Homo sapiens
N-[1-(4-bromophenyl)-4-(ethylamino)-3,4-dioxobutan-2-yl]-N2-[5-(1,2-dithiolan-3-yl)pentanoyl]-L-leucinamide reversible inhibitor Homo sapiens
N2-[(2S)-2-([[(2R,3R)-3-(ethoxycarbonyl)oxiran-2-yl]carbonyl]amino)pent-4-enoyl]-L-arginyl-L-tryptophanamide irreversible inhibitor Homo sapiens
N2-[(benzyloxy)carbonyl]-N-[4-(ethylamino)-3,4-dioxo-1-phenylbutan-2-yl]-L-leucinamide reversible inhibitor Homo sapiens
N-[[(2R,3R)-3-(ethoxycarbonyl)oxiran-2-yl]carbonyl]-L-histidyl-L-arginyl-L-tryptophanamide irreversible inhibitor Homo sapiens
N-[(2S)-1-[[(3S)-2-hydroxytetrahydrofuran-3-yl]amino]-1-oxopentan-2-yl]-10H-phenothiazine-2-carboxamide BN-82204 Homo sapiens
N-[(2S)-1-oxo-3-phenylpropan-2-yl]-7,8-dihydro-2H-[1,4]dioxino[2,3-g][1,2,4]benzothiadiazine-3-carboxamide 1,1-dioxide
-
Homo sapiens
N-[(2S)-3,4-dioxo-1-phenyl-4-([3-[(phenylsulfonyl)amino]propyl]amino)butan-2-yl]-2-ethyl-3,4,7,8-tetrahydro-2H-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxamide 1,1-dioxide reversible inhibitor Homo sapiens
N-[(2S)-4-(2-benzylhydrazinyl)-3,4-dioxo-1-phenylbutan-2-yl]-N2-[(benzyloxy)carbonyl]-L-leucinamide reversible inhibitor Homo sapiens
N-[(2S)-4-(butylamino)-3,4-dioxo-1-phenylbutan-2-yl]-2-ethyl-3,4,7,8-tetrahydro-2H-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxamide 1,1-dioxide reversible inhibitor Homo sapiens
N-(4-amino-3,4-dioxo-1-phenylbutan-2-yl)-1-(1-benzothiophen-2-ylcarbonyl)piperidine-4-carboxamide reversible inhibitor Homo sapiens
N-(4-amino-3,4-dioxo-1-phenylbutan-2-yl)-2-[(E)-2-[4-[(diethylamino)methyl]phenyl]ethenyl]benzamide reversible inhibitor Homo sapiens
N-(4-amino-3,4-dioxo-1-phenylbutan-2-yl)-3-methyl-4-oxo-1,4-dihydroquinoline-2-carboxamide reversible inhibitor Homo sapiens
N-(4-amino-3,4-dioxo-1-phenylbutan-2-yl)-3-methyl-4-oxo-4H-chromene-2-carboxamide reversible inhibitor Homo sapiens
N-(4-amino-3,4-dioxo-1-phenylbutan-2-yl)-4-methyl-6-methylidene-1,6-dihydropyridine-3-carboxamide reversible inhibitor Homo sapiens
N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-4-fluoro-1-(4-hydroxyphenyl)-3-oxobutan-2-yl]-L-leucinamide irreversible inhibitor Homo sapiens
PCP1B peptide
-
Homo sapiens
PD-150606
-
Homo sapiens
PD-151746
-
Homo sapiens
penetratin
-
Homo sapiens
penicillide
-
Homo sapiens
SJA-6017 reversible inhibitor Homo sapiens
SNJ-1715 reversible inhibitor Homo sapiens
SNJ-1945 reversible inhibitor Homo sapiens
ZLLY-CH2F irreversible inhibitor Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.063
-
succinyl-protamine pH and temperature not specified in the publication Homo sapiens
0.00005
-
fodrin pH and temperature not specified in the publication Homo sapiens
0.002
-
succinyl-bovine serum albumin pH and temperature not specified in the publication Homo sapiens
0.2
-
succinyl-L-Leu-L-Leu-L-Val-7-amido-4-methylcoumarin pH and temperature not specified in the publication Homo sapiens
0.2
-
succinyl-L-Leu-L-Leu-L-Val-L-Tyr-7-amido-4-methylcoumarin pH and temperature not specified in the publication Homo sapiens
0.37
-
N-benzyloxycarbonyl-L-Leu-L-Arg-4-methoxy-2-naphthylamide pH and temperature not specified in the publication Homo sapiens
0.0046
-
K-(5(6)-carboxyfluorescein)-EVYGMMK(4-(4-dimethylaminophenylazo)benzoyl)-OH pH and temperature not specified in the publication Homo sapiens
0.19
-
N-benzyloxycarbonyl-L-Leu-L-Arg-7-amido-4-methylcoumarin pH and temperature not specified in the publication Homo sapiens
0.43
-
succinyl-L-Leu-L-Tyr-4-methoxy-2-naphthylamide pH and temperature not specified in the publication Homo sapiens
1.2
-
succinyl-L-Leu-L-Met-7-amido-4-methylcoumarin pH and temperature not specified in the publication Homo sapiens
4.7
-
succinyl-L-Leu-L-Tyr-7-amido-4-methylcoumarin pH and temperature not specified in the publication Homo sapiens
0.053
-
casein pH and temperature not specified in the publication Homo sapiens
0.0081
-
succinyl-casein pH and temperature not specified in the publication Homo sapiens
0.043
-
2-aminobenzoyl-EVYGMMY(3-NO2)-OH pH and temperature not specified in the publication Homo sapiens
0.46
-
N-benzyloxycarbonyl-L-Leu-L-Arg-7-amido-4-trifluoromethylcoumarin pH and temperature not specified in the publication Homo sapiens
5.9
-
tert-butyloxycarbonyl-L-Val-L-Leu-L-Lys-7-amido-4-methylcoumarin pH and temperature not specified in the publication Homo sapiens
0.00074
-
4,4-difluoro-5,7-dimethyl-4-bora-31,4a-diaza-s-indacene-3-propioyl-labeled casein pH and temperature not specified in the publication Homo sapiens
0.0131
-
fluorescin thiocarbamoyl-labeled casein pH and temperature not specified in the publication Homo sapiens
0.284
-
succinyl-insulin B pH and temperature not specified in the publication Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required for activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
casein + H2O
-
Homo sapiens ?
-
?
succinyl-casein + H2O
-
Homo sapiens ?
-
?
succinyl-insulin B + H2O
-
Homo sapiens ?
-
?
succinyl-protamine + H2O
-
Homo sapiens ?
-
?
fodrin + H2O
-
Homo sapiens ?
-
?
(4-(4-dimethylaminophenylazo)benzoyl)-TPLKSPPPSPR-(5[(2-aminoethyl)amino]naphthalene-1-sulfonic acid) + H2O
-
Homo sapiens (4-(4-dimethylaminophenylazo)benzoyl)-TPLK + SPPPSPR-(5[(2-aminoethyl)amino]naphthalene-1-sulfonic acid)
-
?
(5(6)-carboxyfluorescin)-GGGQLYGG-(Nbeta-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-RRK-(5- and 6-carboxytetramethylrhodamine)-OH + H2O
-
Homo sapiens (5(6)-carboxyfluorescin)-GGGQLY + GG-(Nbeta-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-RRK-(5- and 6-carboxytetramethylrhodamine)-OH
-
?
2-aminobenzoyl-EVYGMMY(3-NO2)-OH + H2O
-
Homo sapiens 2-aminobenzoyl-EVY + GMMY(3-NO2)-OH
-
?
4,4-difluoro-5,7-dimethyl-4-bora-31,4a-diaza-s-indacene-3-propioyl-labeled casein + H2O
-
Homo sapiens ?
-
?
5-([4,6-dichlorotriazin-2-yl]amino)fluorescin-labeled microtubule-associated protein 2 + H2O
-
Homo sapiens ?
-
?
7-methoxycoumarin-4-acetyl-GGGNIFGG-(Nbeta-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-KK-OH + H2O
-
Homo sapiens 7-methoxycoumarin-4-acetyl-GGGNIF + GG-(Nbeta-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-KK-OH
-
?
7-methoxycoumarin-4-acetyl-GGGNIYGG-(Nbeta-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-KK-OH + H2O
-
Homo sapiens 7-methoxycoumarin-4-acetyl-GGGNIY + GG-(Nbeta-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-KK-OH
-
?
7-methoxycoumarin-4-acetyl-GGGNLFGG-(Nbeta-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-KK-OH + H2O
-
Homo sapiens 7-methoxycoumarin-4-acetyl-GGGNLF + GG-(Nbeta-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-KK-OH
-
?
7-methoxycoumarin-4-acetyl-GGGNLYGG-(Nbeta-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-KK-OH + H2O
-
Homo sapiens 7-methoxycoumarin-4-acetyl-GGGNLY + GG-(Nbeta-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-KK-OH
-
?
7-methoxycoumarin-4-acetyl-GGGQIFGG-(Nbeta-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-KK-OH + H2O
-
Homo sapiens 7-methoxycoumarin-4-acetyl-GGGQIF + GG-(Nbeta-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-KK-OH
-
?
7-methoxycoumarin-4-acetyl-GGGQLFGG-(Nbeta-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-KK-OH + H2O
-
Homo sapiens 7-methoxycoumarin-4-acetyl-GGGQLF + GG-(Nbeta-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-KK-OH
-
?
7-methoxycoumarin-4-acetyl-GGGQLYGG-(Nbeta-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-KK-OH + H2O
-
Homo sapiens 7-methoxycoumarin-4-acetyl-GGGQLY + GG-(Nbeta-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl)-KK-OH
-
?
N-benzyloxycarbonyl-L-Leu-L-Arg-4-methoxy-2-naphthylamide + H2O
-
Homo sapiens N-benzyloxycarbonyl-L-Leu-L-Arg + 4-methoxy-2-naphthylamine
-
?
N-benzyloxycarbonyl-L-Leu-L-Arg-7-amido-4-methylcoumarin + H2O
-
Homo sapiens N-benzyloxycarbonyl-L-Leu-L-Arg + 7-amino-4-methylcoumarin
-
?
N-benzyloxycarbonyl-L-Leu-L-Arg-7-amido-4-trifluoromethylcoumarin + H2O
-
Homo sapiens N-benzyloxycarbonyl-L-Leu-L-Arg + 7-amino-4-trifluoromethylcoumarin
-
?
fluorescin thiocarbamoyl-labeled casein + H2O
-
Homo sapiens ?
-
?
K-(5(6)-carboxyfluorescein)-EVYGMMK(4-(4-dimethylaminophenylazo)benzoyl)-OH + H2O
-
Homo sapiens K-(5(6)-carboxyfluorescein)-EVY + GMMK(4-(4-dimethylaminophenylazo)benzoyl)-OH
-
?
succinyl-bovine serum albumin + H2O
-
Homo sapiens ?
-
?
succinyl-L-Leu-L-Leu-L-Val-7-amido-4-methylcoumarin + H2O
-
Homo sapiens succinyl-L-Leu-L-Leu-L-Val + 7-amino-4-methylcoumarin
-
?
succinyl-L-Leu-L-Leu-L-Val-L-Tyr-7-amido-4-methylcoumarin + H2O
-
Homo sapiens succinyl-L-Leu-L-Leu-L-Val-L-Tyr + 7-amino-4-methylcoumarin
-
?
succinyl-L-Leu-L-Met-7-amido-4-methylcoumarin + H2O
-
Homo sapiens succinyl-L-Leu-L-Met + 7-amino-4-methylcoumarin
-
?
succinyl-L-Leu-L-Tyr-4-methoxy-2-naphthylamide + H2O
-
Homo sapiens succinyl-L-Leu-L-Tyr + 4-methoxy-2-naphthylamine
-
?
succinyl-L-Leu-L-Tyr-7-amido-4-methylcoumarin + H2O
-
Homo sapiens succinyl-L-Leu-L-Tyr + 7-amino-4-methylcoumarin
-
?
tert-butyloxycarbonyl-L-Leu-L-Met-7-amido-4-methylcoumarin + H2O
-
Homo sapiens tert-butyloxycarbonyl-L-Leu-L-Met + 7-amino-4-methylcoumarin
-
?
tert-butyloxycarbonyl-L-Val-L-Leu-L-Lys-7-amido-4-methylcoumarin + H2O
-
Homo sapiens tert-butyloxycarbonyl-L-Val-L-Leu-L-Lys + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
mu-calpain
-
Homo sapiens
calpain 1
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.52
-
N-benzyloxycarbonyl-L-Leu-L-Arg-4-methoxy-2-naphthylamide pH and temperature not specified in the publication Homo sapiens
0.11
-
K-(5(6)-carboxyfluorescein)-EVYGMMK(4-(4-dimethylaminophenylazo)benzoyl)-OH pH and temperature not specified in the publication Homo sapiens
0.12
-
succinyl-L-Leu-L-Tyr-4-methoxy-2-naphthylamide pH and temperature not specified in the publication Homo sapiens
0.025
-
2-aminobenzoyl-EVYGMMY(3-NO2)-OH pH and temperature not specified in the publication Homo sapiens
0.07
-
N-benzyloxycarbonyl-L-Leu-L-Arg-7-amido-4-trifluoromethylcoumarin pH and temperature not specified in the publication Homo sapiens
0.37
-
succinyl-L-Leu-L-Tyr-7-amido-4-methylcoumarin pH and temperature not specified in the publication Homo sapiens
0.02
-
N-benzyloxycarbonyl-L-Leu-L-Arg-7-amido-4-methylcoumarin pH and temperature not specified in the publication Homo sapiens
0.062
-
succinyl-L-Leu-L-Met-7-amido-4-methylcoumarin pH and temperature not specified in the publication Homo sapiens
0.29
-
succinyl-L-Leu-L-Leu-L-Val-7-amido-4-methylcoumarin pH and temperature not specified in the publication Homo sapiens
0.029
-
succinyl-L-Leu-L-Leu-L-Val-L-Tyr-7-amido-4-methylcoumarin pH and temperature not specified in the publication Homo sapiens
0.49
-
tert-butyloxycarbonyl-L-Val-L-Leu-L-Lys-7-amido-4-methylcoumarin pH and temperature not specified in the publication Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0002
-
N2-[(benzyloxy)carbonyl]-N-[4-(ethylamino)-3,4-dioxo-1-phenylbutan-2-yl]-L-leucinamide pH and temperature not specified in the publication Homo sapiens
0.01
-
ethyl 4-(4-bromophenyl)-3-([N-[5-(1,2-dithiolan-3-yl)pentanoyl]-L-leucyl]amino)-2-oxobutanoate IC50 above 0.01 mM, pH and temperature not specified in the publication Homo sapiens
0.00005
-
4-(4-bromophenyl)-3-([N-[5-(1,2-dithiolan-3-yl)pentanoyl]-L-leucyl]amino)-2-oxobutanoic acid pH and temperature not specified in the publication Homo sapiens
0.017
-
acetyl-DPMSSTYIEE-betaAla-GKREVTIPPKYRELLA-NH2 pH and temperature not specified in the publication Homo sapiens
0.0024
-
acetyl-DPMSSTYIEELGKREVT-betaAla-PPKYRELLA-NH2 pH and temperature not specified in the publication Homo sapiens
0.0018
-
ethyl 3-([N-[(benzyloxy)carbonyl]-L-leucyl]amino)-2-oxo-4-phenylbutanoate pH and temperature not specified in the publication Homo sapiens
0.0000002
-
acetyl-DPMSSTYIEELGKREVTIPPKYRELLA-NH2 pH and temperature not specified in the publication Homo sapiens
0.00002
-
N-[1-(4-bromophenyl)-4-(ethylamino)-3,4-dioxobutan-2-yl]-N2-[5-(1,2-dithiolan-3-yl)pentanoyl]-L-leucinamide pH and temperature not specified in the publication Homo sapiens
0.000026
-
acetyl-SSTTYIEELGKREVTIPPKYR-NH2 pH and temperature not specified in the publication Homo sapiens
0.0000005
-
PCP1B peptide pH and temperature not specified in the publication Homo sapiens
0.00000018
-
penetratin pH and temperature not specified in the publication Homo sapiens
0.000027
-
N-(4-amino-3,4-dioxo-1-phenylbutan-2-yl)-2-[(E)-2-[4-[(diethylamino)methyl]phenyl]ethenyl]benzamide pH and temperature not specified in the publication Homo sapiens
0.0000047
-
N-[(2S)-4-(2-benzylhydrazinyl)-3,4-dioxo-1-phenylbutan-2-yl]-N2-[(benzyloxy)carbonyl]-L-leucinamide pH and temperature not specified in the publication Homo sapiens
0.000009
-
N-(4-amino-3,4-dioxo-1-phenylbutan-2-yl)-1-(1-benzothiophen-2-ylcarbonyl)piperidine-4-carboxamide pH and temperature not specified in the publication Homo sapiens
0.00000019
-
acetyl-RRMKWKKDPMSSTYIEELGKREVTIPPKYRELLA-NH2 pH and temperature not specified in the publication Homo sapiens
0.000093
-
acetyl-TYIEELGKREVTIPPKYR-NH2 pH and temperature not specified in the publication Homo sapiens
0.000081
-
1-[(4-methylphenyl)sulfonyl]-N-(1-oxo-3-phenylpropan-2-yl)-D-prolinamide pH and temperature not specified in the publication Homo sapiens
0.0000085
-
3-([N-[(benzyloxy)carbonyl]-L-leucyl]amino)-2-oxo-4-phenylbutanoic acid pH and temperature not specified in the publication Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0015
-
-
Homo sapiens E-64
0.0004
-
pH and temperature not specified in the publication Homo sapiens benzyl [(6S,9S,12S)-6-formyl-9-(2-methylpropyl)-8,11-dioxo-2-oxa-7,10-diazabicyclo[12.2.2]octadeca-1(16),14,17-trien-12-yl]carbamate
0.001
-
IC50 above 0.001 mM, pH and temperature not specified in the publication Homo sapiens (3S)-3-[[N-(10H-phenothiazin-2-ylcarbonyl)-L-norvalyl]amino]tetrahydrofuran-2-yl acetate
0.0005
-
pH and temperature not specified in the publication Homo sapiens 1-(2-chloro-4-hydroxyphenyl)-4-oxo-7-(pyridin-4-yl)-1,4-dihydroquinoline-3-carboxamide
0.00022
-
pH and temperature not specified in the publication Homo sapiens benzyl [(7S,10S,13S)-7-formyl-10-(2-methylpropyl)-9,12-dioxo-2-oxa-8,11-diazabicyclo[13.2.2]nonadeca-1(17),15,18-trien-13-yl]carbamate
0.00096
-
pH and temperature not specified in the publication Homo sapiens 5-formyl-N-[(2S)-3-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxobutan-2-yl]furan-2-carboxamide
0.00044
-
pH and temperature not specified in the publication Homo sapiens 5-formyl-N-[(2S)-3-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxobutan-2-yl]thiophene-2-carboxamide
0.029
-
pH and temperature not specified in the publication Homo sapiens (7S,10S,13S,26S)-13,26-dibenzyl-7-methyl-10-(propan-2-yl)-5,7,8,10,11,13,14,25,26,28-decahydrotetrabenzo[k,m,t,v][1,4,7,10,15,18]hexaazacyclotetracosine-6,9,12,15,24,27-hexone
0.00004
-
pH and temperature not specified in the publication Homo sapiens N-(4-amino-3,4-dioxo-1-phenylbutan-2-yl)-3-methyl-4-oxo-4H-chromene-2-carboxamide
0.00028
-
pH and temperature not specified in the publication Homo sapiens 3-acetyl-8-chloro-2-[(2,4-dibromophenyl)amino]-5-methylquinolin-4(1H)-one
0.000006
-
pH and temperature not specified in the publication Homo sapiens 2-methyl-N-[(2S)-1-oxo-3-phenylpropan-2-yl]-7,8-dihydro-2H-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxamide 1,1-dioxide
0.000038
-
pH and temperature not specified in the publication Homo sapiens (3S)-2-hydroxytetrahydrofuran-3-yl N-[(10H-phenothiazin-2-yloxy)acetyl]-L-threonyl-L-leucinate
0.0007
-
pH and temperature not specified in the publication Homo sapiens (2S,5S)-5-benzyl-6-hydroxy-2-(2-methylpropyl)morpholin-3-one
0.00033
-
pH and temperature not specified in the publication Homo sapiens 5-azanylidyne-N-[[(2S,3S)-3-(ethoxycarbonyl)oxiran-2-yl]carbonyl]-L-norvalyl-L-arginyl-L-tryptophanamide
0.00017
-
pH and temperature not specified in the publication Homo sapiens benzyl [(8S,11S,14S)-8-formyl-11-(2-methylpropyl)-10,13-dioxo-2-oxa-9,12-diazabicyclo[14.2.2]icosa-1(18),16,19-trien-14-yl]carbamate
0.00029
-
pH and temperature not specified in the publication Homo sapiens 5-formyl-N-[(2S)-3-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxobutan-2-yl]-1H-pyrrole-2-carboxamide
0.00034
-
pH and temperature not specified in the publication Homo sapiens 3-([4-[2-(methoxymethoxy)phenyl]-4-oxobutanoyl]amino)-2-oxo-4-phenylbutanamide
0.000035
-
pH and temperature not specified in the publication Homo sapiens N-[(2S)-3,4-dioxo-1-phenyl-4-([3-[(phenylsulfonyl)amino]propyl]amino)butan-2-yl]-2-ethyl-3,4,7,8-tetrahydro-2H-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxamide 1,1-dioxide
0.00005
-
pH and temperature not specified in the publication Homo sapiens N-[(2S)-4-(butylamino)-3,4-dioxo-1-phenylbutan-2-yl]-2-ethyl-3,4,7,8-tetrahydro-2H-[1,4]dioxino[2,3-g][1,2]benzothiazine-3-carboxamide 1,1-dioxide
0.0028
-
pH and temperature not specified in the publication Homo sapiens N-(4-amino-3,4-dioxo-1-phenylbutan-2-yl)-4-methyl-6-methylidene-1,6-dihydropyridine-3-carboxamide
0.00078
-
pH and temperature not specified in the publication Homo sapiens N2-[(2S)-2-([[(2R,3R)-3-(ethoxycarbonyl)oxiran-2-yl]carbonyl]amino)pent-4-enoyl]-L-arginyl-L-tryptophanamide
0.00071
-
pH and temperature not specified in the publication Homo sapiens N-(4-amino-3,4-dioxo-1-phenylbutan-2-yl)-3-methyl-4-oxo-1,4-dihydroquinoline-2-carboxamide
0.000023
-
pH and temperature not specified in the publication Homo sapiens N-[(2S)-1-[[(3S)-2-hydroxytetrahydrofuran-3-yl]amino]-1-oxopentan-2-yl]-10H-phenothiazine-2-carboxamide
0.000028
-
pH and temperature not specified in the publication Homo sapiens N-[(2S)-1-oxo-3-phenylpropan-2-yl]-7,8-dihydro-2H-[1,4]dioxino[2,3-g][1,2,4]benzothiadiazine-3-carboxamide 1,1-dioxide
0.000064
-
pH and temperature not specified in the publication Homo sapiens dimethyl (2S,2'S)-2,2'-[biphenyl-2,2'-diylbis(carbonylimino)]bis(3-phenylpropanoate)
0.00088
-
pH and temperature not specified in the publication Homo sapiens (2S)-2-[[(4-fluorophenyl)sulfonyl]amino]-N-[(3S)-2-hydroxytetrahydrofuran-3-yl]-3-methylbutanamide
0.000089
-
pH and temperature not specified in the publication Homo sapiens (3S)-2-hydroxytetrahydrofuran-3-yl N-[(2S)-2-[[(10H-phenothiazin-2-yloxy)acetyl]amino]butanoyl]-L-leucinate
0.000000087
-
pH and temperature not specified in the publication Homo sapiens methyl N-[[2'-([(2S)-1-[(2'-aminobiphenyl-2-yl)amino]-1-oxo-3-phenylpropan-2-yl]carbamoyl)biphenyl-2-yl]carbonyl]-L-phenylalanyl-L-valinate