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Literature summary for 3.4.22.52 extracted from

  • Murphy, R.M.
    Calpains, skeletal muscle function and exercise (2010), Clin. Exp. Pharmacol. Physiol., 37, 385-391.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on (0.002-0.02 mM). At resting [Ca2+], mu-calpain is present predominantly in its full-length, unautolysed/unactivated forms. Once activated, mu-calpain appears in its autolysed form. Endogenously expressed mu-calpain is activated within a physiological [Ca2+] range in a Ca2+- and time-dependent manner. Autolysed mu-calpain isoforms have a greater Ca2+ sensitivity than the full-length 80000 Da isoform Homo sapiens
Ca2+ dependent on (0.002-0.02 mM). At resting [Ca2+], mu-calpain is present predominantly in its full-length, unautolysed/unactivated forms. Once activated, mu-calpain appears in its autolysed form. Endogenously expressed mu-calpain is activated within a physiological [Ca2+] range in a Ca2+- and time-dependent manner. Autolysed mu-calpain isoforms have a greater Ca2+ sensitivity than the full-length 80000 Da isoform Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
full-length isoform Homo sapiens
80000
-
full-length isoform Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha-actinin + H2O Homo sapiens
-
?
-
?
alpha-actinin + H2O Rattus norvegicus
-
?
-
?
desmin + H2O Homo sapiens
-
?
-
?
desmin + H2O Rattus norvegicus
-
?
-
?
fodrin + H2O Homo sapiens
-
?
-
?
fodrin + H2O Rattus norvegicus
-
?
-
?
spectrin + H2O Homo sapiens
-
?
-
?
spectrin + H2O Rattus norvegicus
-
?
-
?
titin + H2O Homo sapiens
-
?
-
?
titin + H2O Rattus norvegicus
-
?
-
?
troponin complex + H2O Homo sapiens
-
?
-
?
troponin complex + H2O Rattus norvegicus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle in skeletal muscle, mu-calpain is a freely diffusible protein Homo sapiens
-
skeletal muscle in skeletal muscle, mu-calpain is a freely diffusible protein Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-actinin + H2O
-
Homo sapiens ?
-
?
alpha-actinin + H2O
-
Rattus norvegicus ?
-
?
desmin + H2O
-
Homo sapiens ?
-
?
desmin + H2O
-
Rattus norvegicus ?
-
?
fodrin + H2O
-
Homo sapiens ?
-
?
fodrin + H2O
-
Rattus norvegicus ?
-
?
spectrin + H2O
-
Homo sapiens ?
-
?
spectrin + H2O
-
Rattus norvegicus ?
-
?
titin + H2O
-
Homo sapiens ?
-
?
titin + H2O
-
Rattus norvegicus ?
-
?
troponin complex + H2O
-
Homo sapiens ?
-
?
troponin complex + H2O
-
Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
mu-calpain
-
Homo sapiens
mu-calpain
-
Rattus norvegicus

Expression

Organism Comment Expression
Homo sapiens mu-calpain is not activated immediately following sprint, endurance or eccentric exercise. mu-Calpain is not activated 24 h after a single bout of eccentric exercise additional information
Rattus norvegicus mu-calpain is not activated immediately following sprint, endurance or eccentric exercise. mu-Calpain is not activated 24 h after a single bout of eccentric exercise additional information

General Information

General Information Comment Organism
physiological function mu-calpain plays a role in membrane repair and a protective role in skeletal muscle Homo sapiens
physiological function mu-calpain plays a role in membrane repair and a protective role in skeletal muscle Rattus norvegicus