Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on (0.002-0.02 mM). At resting [Ca2+], mu-calpain is present predominantly in its full-length, unautolysed/unactivated forms. Once activated, mu-calpain appears in its autolysed form. Endogenously expressed mu-calpain is activated within a physiological [Ca2+] range in a Ca2+- and time-dependent manner. Autolysed mu-calpain isoforms have a greater Ca2+ sensitivity than the full-length 80000 Da isoform | Homo sapiens | |
Ca2+ | dependent on (0.002-0.02 mM). At resting [Ca2+], mu-calpain is present predominantly in its full-length, unautolysed/unactivated forms. Once activated, mu-calpain appears in its autolysed form. Endogenously expressed mu-calpain is activated within a physiological [Ca2+] range in a Ca2+- and time-dependent manner. Autolysed mu-calpain isoforms have a greater Ca2+ sensitivity than the full-length 80000 Da isoform | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
80000 | - |
full-length isoform | Homo sapiens |
80000 | - |
full-length isoform | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-actinin + H2O | Homo sapiens | - |
? | - |
? | |
alpha-actinin + H2O | Rattus norvegicus | - |
? | - |
? | |
desmin + H2O | Homo sapiens | - |
? | - |
? | |
desmin + H2O | Rattus norvegicus | - |
? | - |
? | |
fodrin + H2O | Homo sapiens | - |
? | - |
? | |
fodrin + H2O | Rattus norvegicus | - |
? | - |
? | |
spectrin + H2O | Homo sapiens | - |
? | - |
? | |
spectrin + H2O | Rattus norvegicus | - |
? | - |
? | |
titin + H2O | Homo sapiens | - |
? | - |
? | |
titin + H2O | Rattus norvegicus | - |
? | - |
? | |
troponin complex + H2O | Homo sapiens | - |
? | - |
? | |
troponin complex + H2O | Rattus norvegicus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skeletal muscle | in skeletal muscle, mu-calpain is a freely diffusible protein | Homo sapiens | - |
skeletal muscle | in skeletal muscle, mu-calpain is a freely diffusible protein | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-actinin + H2O | - |
Homo sapiens | ? | - |
? | |
alpha-actinin + H2O | - |
Rattus norvegicus | ? | - |
? | |
desmin + H2O | - |
Homo sapiens | ? | - |
? | |
desmin + H2O | - |
Rattus norvegicus | ? | - |
? | |
fodrin + H2O | - |
Homo sapiens | ? | - |
? | |
fodrin + H2O | - |
Rattus norvegicus | ? | - |
? | |
spectrin + H2O | - |
Homo sapiens | ? | - |
? | |
spectrin + H2O | - |
Rattus norvegicus | ? | - |
? | |
titin + H2O | - |
Homo sapiens | ? | - |
? | |
titin + H2O | - |
Rattus norvegicus | ? | - |
? | |
troponin complex + H2O | - |
Homo sapiens | ? | - |
? | |
troponin complex + H2O | - |
Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
mu-calpain | - |
Homo sapiens |
mu-calpain | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | mu-calpain is not activated immediately following sprint, endurance or eccentric exercise. mu-Calpain is not activated 24 h after a single bout of eccentric exercise | additional information |
Rattus norvegicus | mu-calpain is not activated immediately following sprint, endurance or eccentric exercise. mu-Calpain is not activated 24 h after a single bout of eccentric exercise | additional information |
General Information | Comment | Organism |
---|---|---|
physiological function | mu-calpain plays a role in membrane repair and a protective role in skeletal muscle | Homo sapiens |
physiological function | mu-calpain plays a role in membrane repair and a protective role in skeletal muscle | Rattus norvegicus |