Literature summary for 3.4.22.52 extracted from

  • Dean, P.; Muehlen, S.; Quitard, S.; Kenny, B.
    The bacterial effectors EspG and EspG2 induce a destructive calpain activity that is kept in check by the co-delivered Tir effector (2010), Cell. Microbiol., 12, 1308-1321.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
calpain inhibitor III
-
Homo sapiens
calpeptin
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2/TC7 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-succinyl-LLVY-7-amido-4-methylcoumarin + H2O
-
Homo sapiens N-succinyl-LLVY + 7-amino-4-methylcoumarin
-
?

Synonyms

Synonyms Comment Organism
calpain I
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens although the levels of the calpain I isoform are higher in the soluble and insoluble fractions of tir- and wild type enteropathogenic Escherichia coli (E2348/69 O127:H6)-infected cells, their levels are not significantly different to the TTSS-negative control up