Literature summary for 3.4.22.52 extracted from

  • Levesque, S.; Wilson, B.; Gregoria, V.; Thorpe, L.B.; Dallas, S.; Polikov, V.S.; Hong, J.S.; Block, M.L.
    Reactive microgliosis: extracellular micro-calpain and microglia-mediated dopaminergic neurotoxicity (2010), Brain, 133, 808-821.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
N-27 cell
-
Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
micro-calpain
-
Rattus norvegicus

General Information

General Information Comment Organism
physiological function micro-calpain is a key signal released from 1-methyl-4-phenylpyridinium-damaged neurons, causing selective dopaminergic neuron death through activation of microglial NADPH oxidase and superoxide production. Extracellular micro-calpain activates microglia Rattus norvegicus