Literature summary for 3.4.22.52 extracted from

  • Jiao, W.; McDonald, D.Q.; Coxon, J.M.; Parker, E.J.
    Molecular modeling studies of peptide inhibitors highlight the importance of conformational prearrangement for inhibition of calpain (2010), Biochemistry, 49, 5533-5539.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
CP1B peptide a 20-mer peptide truncated from region B of calpastatin inhibitory domain 1, 1000fold more selective for mu-calpain than cathepsin L Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ requires a micromolar concentration of calcium ions Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
mu-calpain
-
Homo sapiens
calpain 1
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000026
-
CP1B peptide pH and temperature not specified in the publication Homo sapiens