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Literature summary for 3.4.22.52 extracted from

  • Verburg, E.; Murphy, R.M.; Richard, I.; Lamb, G.D.
    Involvement of calpains in Ca2+-induced disruption of excitation-contraction coupling in mammalian skeletal muscle fibers (2009), Am. J. Physiol. Cell Physiol., 296, C1115-C1122.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
leupeptin
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ mu-calpain is autolytically activated at micromolar Ca2+, mice muscle fibers that are partially excitation-contraction uncoupled by exposure to 0.005 mM Ca2+ for 3 min (no ATP) show the presence of autolytic activation of a proportion of the human mu-calpain present Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
titin + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
mu-calpain
-
Homo sapiens

General Information

General Information Comment Organism
physiological function mu-calpain is responsible for Ca2+-induced disruption of excitation-contraction coupling Homo sapiens