Literature summary for 3.4.22.52 extracted from

  • Badugu, R.; Garcia, M.; Bondada, V.; Joshi, A.; Geddes, J.W.
    N terminus of calpain 1 is a mitochondrial targeting sequence (2008), J. Biol. Chem., 283, 3409-3417.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion both calpain 1 and calpain small subunit 1, which together form mu-calpain, are present in the mitochondrial intermembrane space. The N-terminus of calpain 1 is not processed following mitochondrial import, but is removed by autolysis following calpain activation. Calpain small subunit 1 is not directly imported into mitochondria, but is imported in the presence of calpain 1. The presence of a mitochondrial targeting sequence in the N-terminal region of calpain 1 is consistent with the localization of mu-calpain to the mitochondrial intermembrane space Homo sapiens
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mitochondrion both calpain 1 and calpain small subunit 1, which together form mu-calpain, are present in the mitochondrial intermembrane space. The N-terminus of calpain 1 is not processed following mitochondrial import, but is removed by autolysis following calpain activation. Calpain small subunit 1 is not directly imported into mitochondria, but is imported in the presence of calpain 1. The presence of a mitochondrial targeting sequence in the N-terminal region of calpain 1 is consistent with the localization of mu-calpain to the mitochondrial intermembrane space Rattus norvegicus
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
cerebral cortex
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Rattus norvegicus
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SH-SY5Y cell neuroblastoma Homo sapiens
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