Literature summary for 3.4.22.52 extracted from

  • Fernandez-Montalvan, A.; Assfalg-Machleidt, I.; Pfeiler, D.; Fritz, H.; Jochum, M.; Machleidt, W.
    mu-Calpain binds to lipid bilayers via the exposed hydrophobic surface of its Ca2+-activated conformation (2006), Biol. Chem., 387, 617-627.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Ca2+ required for activation of mu-calpain. Membrane-binding of mu-calpain is Ca2+-dependent. Membrane binding of mu-calpain is due to the exposed hydrophobic surface of the active site conformation and does not reduce the Ca2+ requirement for activation Homo sapiens

Engineering

Protein Variants Comment Organism
C115A non-autolysing active-site mutant Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane membrane-binding of mu-calpain is Ca2+-dependent. Membrane binding of mu-calpain is due to the exposed hydrophobic surface of the active site conformation and does not reduce the Ca2+ requirement for activation Homo sapiens
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Synonyms

Synonyms Comment Organism
mu-calpain
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Homo sapiens