Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-(2-chlorophenyl)-1-(4-bromophenyl)prop-2-en-1-one | - |
Capra hircus | |
3-(2-chlorophenyl)-1-(naphthalen-3-yl)prop-2-en-1-one | - |
Capra hircus | |
3-(2-chlorophenyl)-1-(pyridin-2-yl)prop-2-en-1-one | - |
Capra hircus | |
3-(2-chlorophenyl)-1-(thien-2-yl)prop-2-en-1-one | - |
Capra hircus | |
3-(3-chlorophenyl)-1-(4-aminophenyl)prop-2-en-1-one | - |
Capra hircus | |
3-(3-chlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one | - |
Capra hircus | |
3-(3-chlorophenyl)-1-(4-hydroxyphenyl)-prop-2-en-1-one | - |
Capra hircus | |
3-(3-chlorophenyl)-1-(furan-2-yl)prop-2-en-1-one | - |
Capra hircus | |
3-(4-chlorophenyl)-1-(4-(N'-4-nitrophenyl)methylene)aminophenyl)prop-2-en-1-one | - |
Capra hircus | |
3-(4-chlorophenyl)-1-(4-methylphenyl)prop-2-en-1-one | - |
Capra hircus | |
3-(4-chlorophenyl)-1-(4-nitrophenyl)prop-2-en-1-one | - |
Capra hircus | |
additional information | synthesis of a small library of chalcones and study of their role as inhibitors of cathepsins, overview. The most potent inhibitors among all compounds are chloro-substituted compounds for cathepsin H. Docking analysis and modeling, overview | Capra hircus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Capra hircus | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Capra hircus | A0A060INS8 | - |
- |
Purification (Comment) | Organism |
---|---|
native enzyme from liver homogenate by acetone powder preparation, acid autolysis, ammonium sulfate fractionation, gel filtration, cation exchange and anion exchange chromatography, and again gel filtration | Capra hircus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Capra hircus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.02291 | - |
purified native enzyme, pH 5.0, 37°C | Capra hircus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Leu-2-naphthylamide + H2O | - |
Capra hircus | leucine + 2-naphthylamine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CTSH | - |
Capra hircus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Capra hircus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5 | - |
assay at | Capra hircus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0133 | - |
3-(4-chlorophenyl)-1-(4-(N'-4-nitrophenyl)methylene)aminophenyl)prop-2-en-1-one | pH 5.0, 37°C | Capra hircus | |
0.0214 | - |
3-(2-chlorophenyl)-1-(4-bromophenyl)prop-2-en-1-one | pH 5.0, 37°C | Capra hircus | |
0.0317 | - |
3-(3-chlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one | pH 5.0, 37°C | Capra hircus | |
0.0416 | - |
3-(4-chlorophenyl)-1-(4-methylphenyl)prop-2-en-1-one | pH 5.0, 37°C | Capra hircus | |
0.0472 | - |
3-(2-chlorophenyl)-1-(pyridin-2-yl)prop-2-en-1-one | pH 5.0, 37°C | Capra hircus | |
0.0989 | - |
3-(2-chlorophenyl)-1-(naphthalen-3-yl)prop-2-en-1-one | pH 5.0, 37°C | Capra hircus | |
0.128 | - |
3-(3-chlorophenyl)-1-(4-aminophenyl)prop-2-en-1-one | pH 5.0, 37°C | Capra hircus | |
0.163 | - |
3-(3-chlorophenyl)-1-(4-hydroxyphenyl)-prop-2-en-1-one | pH 5.0, 37°C | Capra hircus | |
0.217 | - |
3-(2-chlorophenyl)-1-(thien-2-yl)prop-2-en-1-one | pH 5.0, 37°C | Capra hircus | |
0.298 | - |
3-(3-chlorophenyl)-1-(furan-2-yl)prop-2-en-1-one | pH 5.0, 37°C | Capra hircus | |
0.405 | - |
3-(4-chlorophenyl)-1-(4-nitrophenyl)prop-2-en-1-one | pH 5.0, 37°C | Capra hircus |