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Literature summary for 3.4.22.16 extracted from

  • Raghav, N.; Singh, M.
    SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H (2014), Bioorg. Med. Chem., 22, 4233-4245.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,3,5-triphenyl pyrazole
-
Capra hircus
1,3,5-triphenyl-2-pyrazoline
-
Capra hircus
3,5-diphenyl-2-pyrazoline
-
Capra hircus
4-bromochalcone phenyl hydrazone
-
Capra hircus
4-chlorochalcone phenyl hydrazone
-
Capra hircus
4-methoxychalcone phenyl hydrazone
-
Capra hircus
4-methylchalcone phenyl hydrazone
-
Capra hircus
4-nitrochalcone phenyl hydrazone
-
Capra hircus
5-(4-bromophenyl)-1,3-diphenyl pyrazole
-
Capra hircus
5-(4-bromophenyl)-1,3-diphenyl-2-pyrazoline
-
Capra hircus
5-(4-bromophenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
5-(4-chlorophenyl)-1,3-diphenyl pyrazole
-
Capra hircus
5-(4-chlorophenyl)-1,3-diphenyl-2-pyrazoline
-
Capra hircus
5-(4-chlorophenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
5-(4-methoxyphenyl)-1,3-diphenyl pyrazole
-
Capra hircus
5-(4-methoxyphenyl)-1,3-diphenyl-2-pyrazoline
-
Capra hircus
5-(4-methoxyphenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
5-(4-methylphenyl)-1,3-diphenyl pyrazole
-
Capra hircus
5-(4-methylphenyl)-1,3-diphenyl-2-pyrazoline
-
Capra hircus
5-(4-methylphenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
5-(4-nitrophenyl)-1,3-diphenyl pyrazole
-
Capra hircus
5-(4-nitrophenyl)-1,3-diphenyl-2-pyrazoline
-
Capra hircus
5-(4-nitrophenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
chalcone phenyl hydrazone
-
Capra hircus
N-acetyl-3,5-diphenyl pyrazolines
-
Capra hircus
N-acetyl-5-(4-bromophenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
N-acetyl-5-(4-chlorophenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
N-acetyl-5-(4-methoxyphenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
N-acetyl-5-(4-methylphenyl)-3-phenyl-2-pyrazoline
-
Capra hircus
N-acetyl-5-(4-nitrophenyl)-3-phenyl-2-pyrazoline
-
Capra hircus

Organism

Organism UniProt Comment Textmining
Capra hircus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Capra hircus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.02256
-
pH 7, 37°C Capra hircus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Leu-2-naphthylamide + H2O
-
Capra hircus L-Leu + 2-naphthylamine
-
?

Synonyms

Synonyms Comment Organism
cathepsin H
-
Capra hircus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Capra hircus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Capra hircus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0011
-
4-chlorochalcone phenyl hydrazone pH 7, 37°C Capra hircus
0.001174
-
5-(4-chlorophenyl)-1,3-diphenyl-2-pyrazoline pH 7, 37°C Capra hircus
0.001568
-
5-(4-chlorophenyl)-3-phenyl-2-pyrazoline pH 7, 37°C Capra hircus
0.001695
-
4-methoxychalcone phenyl hydrazone pH 7, 37°C Capra hircus
0.001905
-
4-nitrochalcone phenyl hydrazone pH 7, 37°C Capra hircus
0.002119
-
5-(4-methoxyphenyl)-1,3-diphenyl-2-pyrazoline pH 7, 37°C Capra hircus
0.002346
-
5-(4-chlorophenyl)-1,3-diphenyl pyrazole pH 7, 37°C Capra hircus
0.00257
-
5-(4-nitrophenyl)-1,3-diphenyl pyrazole pH 7, 37°C Capra hircus
0.0026
-
4-bromochalcone phenyl hydrazone pH 7, 37°C Capra hircus
0.0029
-
4-methylchalcone phenyl hydrazone pH 7, 37°C Capra hircus
0.002907
-
5-(4-bromophenyl)-1,3-diphenyl-2-pyrazoline pH 7, 37°C Capra hircus
0.003158
-
5-(4-nitrophenyl)-1,3-diphenyl-2-pyrazoline pH 7, 37°C Capra hircus
0.0033
-
5-(4-methoxyphenyl)-1,3-diphenyl pyrazole pH 7, 37°C Capra hircus
0.0033
-
5-(4-nitrophenyl)-3-phenyl-2-pyrazoline pH 7, 37°C Capra hircus
0.0038
-
5-(4-bromophenyl)-1,3-diphenyl pyrazole pH 7, 37°C Capra hircus
0.004184
-
5-(4-methylphenyl)-1,3-diphenyl-2-pyrazoline pH 7, 37°C Capra hircus
0.0048
-
chalcone phenyl hydrazone pH 7, 37°C Capra hircus
0.00537
-
5-(4-bromophenyl)-3-phenyl-2-pyrazoline pH 7, 37°C Capra hircus
0.005388
-
1,3,5-triphenyl-2-pyrazoline pH 7, 37°C Capra hircus
0.006024
-
3,5-diphenyl-2-pyrazoline pH 7, 37°C Capra hircus
0.007396
-
5-(4-methylphenyl)-1,3-diphenyl pyrazole pH 7, 37°C Capra hircus
0.0082
-
5-(4-methylphenyl)-3-phenyl-2-pyrazoline pH 7, 37°C Capra hircus
0.0098
-
5-(4-methoxyphenyl)-3-phenyl-2-pyrazoline pH 7, 37°C Capra hircus
0.01
-
N-acetyl-5-(4-chlorophenyl)-3-phenyl-2-pyrazoline pH 7, 37°C Capra hircus
0.01266
-
N-acetyl-5-(4-bromophenyl)-3-phenyl-2-pyrazoline pH 7, 37°C Capra hircus
0.01767
-
N-acetyl-3,5-diphenyl pyrazolines pH 7, 37°C Capra hircus
0.01859
-
1,3,5-triphenyl pyrazole pH 7, 37°C Capra hircus
0.02432
-
N-acetyl-5-(4-nitrophenyl)-3-phenyl-2-pyrazoline pH 7, 37°C Capra hircus
0.03546
-
N-acetyl-5-(4-methylphenyl)-3-phenyl-2-pyrazoline pH 7, 37°C Capra hircus
0.14
-
N-acetyl-5-(4-methoxyphenyl)-3-phenyl-2-pyrazoline pH 7, 37°C Capra hircus