Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1H-spiro(cyclohexane-1,2-quinazolin)-4(3H)-one | competitive inhibition, 94.86% residual activity at 0.1 mM | Capra hircus | |
2-(4-(dimethylamino)phenyl)-2,3-dihydroquinazolin-4(1H)-one | competitive inhibition, 88.37% residual activity at 0.1 mM | Capra hircus | |
2-(4-bromophenyl)-2,3-dihydroquinazolin-4(1H)-one | competitive inhibition, 91.62% residual activity at 0.1 mM | Capra hircus | |
2-(4-chlorophenyl)-2,3-dihydroquinazolin-4(1H)-one | competitive inhibition, 98.11% residual activity at 0.1 mM | Capra hircus | |
2-(4-fluorophenyl)-2,3-dihydroquinazolin-4(1H)-one | competitive inhibition, 94.05% residual activity at 0.1 mM | Capra hircus | |
2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one | competitive inhibition, 95.94% residual activity at 0.1 mM | Capra hircus | |
2-(4-methylphenyl)-2,3-dihydroquinazolin-4(1H)-one | competitive inhibition, 39.18% residual activity at 0.1 mM | Capra hircus | |
2-(4-nitrophenyl)-2,3-dihydroquinazolin-4(1H)-one | competitive inhibition, 81.89% residual activity at 0.1 mM | Capra hircus | |
2-phenyl-2,3-dihydroquinazolin-4(1H)-one | competitive inhibition, 79.73% residual activity at 0.1 mM | Capra hircus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Capra hircus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
ammonium sulfate precipitation, CM-Sephadex column chromatography, C-50 column chromatography, DEAE-Sephadex A-50., and Sephadex G-100, and gel filtration | Capra hircus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Capra hircus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Leu-2-naphthylamide + H2O | - |
Capra hircus | L-Leu + 2-naphthylamine | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0025 | - |
2-(4-methylphenyl)-2,3-dihydroquinazolin-4(1H)-one | at pH 7.0 and 37°C | Capra hircus | |
0.00818 | - |
2-(4-fluorophenyl)-2,3-dihydroquinazolin-4(1H)-one | at pH 7.0 and 37°C | Capra hircus | |
0.01042 | - |
2-(4-nitrophenyl)-2,3-dihydroquinazolin-4(1H)-one | at pH 7.0 and 37°C | Capra hircus | |
0.01441 | - |
2-phenyl-2,3-dihydroquinazolin-4(1H)-one | at pH 7.0 and 37°C | Capra hircus | |
0.01858 | - |
2-(4-(dimethylamino)phenyl)-2,3-dihydroquinazolin-4(1H)-one | at pH 7.0 and 37°C | Capra hircus | |
0.02325 | - |
2-(4-chlorophenyl)-2,3-dihydroquinazolin-4(1H)-one | at pH 7.0 and 37°C | Capra hircus | |
0.05263 | - |
2-(4-bromophenyl)-2,3-dihydroquinazolin-4(1H)-one | at pH 7.0 and 37°C | Capra hircus | |
0.05682 | - |
2-(4-methoxyphenyl)-2,3-dihydroquinazolin-4(1H)-one | at pH 7.0 and 37°C | Capra hircus | |
0.09009 | - |
1H-spiro(cyclohexane-1,2-quinazolin)-4(3H)-one | at pH 7.0 and 37°C | Capra hircus |