Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no significant inhibitory effect of enzyme propeptide fragments, detailed analysis using several different peptides. Recombinant enzyme lacking the mini-chain shows inhibitory interaction | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09668 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | propeptide-binding region of enzyme is structurally rearranged during maturation processing and mini-chain formation, which impairs the effective recognition of mature enzyme by its propeptide | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Arg-4-methylcoumaryl-7-amide + H2O | - |
Homo sapiens | Arg + 7-amino-4-methylcoumarin | - |
? | |
benzoyl-L-Phe-L-Val-L-Arg-4-methylcoumaryl-7-amide + H2O | - |
Homo sapiens | benzoyl-L-Phe-L-Val-L-Arg + 7-amino-4-methylcoumarin | - |
? |