KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.7 | - |
succinyl-Ala-Ala-Ala-Ala-4-nitroanilide | - |
Rattus norvegicus | |
0.7 | - |
succinyl-Ala-Ala-Ala-Ala-Ala-4-nitroanilide | - |
Rattus norvegicus | |
2.9 | - |
succinyl-Pro-Ala-Ala-4-nitroanilide | - |
Rattus norvegicus | |
3 | - |
succinyl-Ala-Pro-Ala-4-nitroanilide | - |
Rattus norvegicus | |
3.5 | - |
benzyloxycarbonyl-Pro-Ala-Ala-Ala-Pro-NH2 | - |
Rattus norvegicus | |
7 | - |
succinyl-Ala-Ala-Ala-4-nitroanilide | - |
Rattus norvegicus | |
7.4 | - |
benzyloxycarbonyl-Pro-Ala-Ala-Ala-Pro | - |
Rattus norvegicus | |
10.2 | - |
succinyl-Ala-Ala-4-nitroanilide | - |
Rattus norvegicus | |
27.8 | - |
succinyl-Ala-Ala-Pro-4-nitroanilide | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Proteins + H2O | Rattus norvegicus | rather broad specificity of aminopeptidase activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
Hydrolysis of proteins, acting as an aminopeptidase (notably, cleaving Arg-/- bonds) as well as an endopeptidase | number of possible subsites: three | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-Ala-4-nitroanilide + H2O | - |
Rattus norvegicus | acetyl-Ala + 4-nitroaniline | - |
ir | |
benzyloxycarbonyl-Pro-Ala-Ala-Ala-Pro + H2O | - |
Rattus norvegicus | benzyloxycarbonyl-Pro-Ala-Ala-Ala + Pro | - |
ir | |
benzyloxycarbonyl-Pro-Ala-Ala-Ala-Pro-NH2 + H2O | - |
Rattus norvegicus | benzyloxycarbonyl-Pro-Ala-Ala-Ala + Pro-NH2 | - |
ir | |
additional information | influence of Pro in position P1 to P3 on rate of peptide hydrolysis, P3 i.e. 3rd amino acid in N-terminal direction relative to point of cleavage, greatest increase in activity after substrate elongation to tetrapeptide | Rattus norvegicus | ? | - |
? | |
Proteins + H2O | rather broad specificity of aminopeptidase activity | Rattus norvegicus | ? | - |
? | |
succinyl-Ala-Ala-4-nitroanilide + H2O | - |
Rattus norvegicus | succinyl-Ala-Ala + 4-nitroaniline | - |
ir | |
succinyl-Ala-Ala-Ala-4-nitroanilide + H2O | - |
Rattus norvegicus | succinyl-Ala-Ala-Ala + 4-nitroaniline | - |
ir | |
succinyl-Ala-Ala-Ala-Ala-4-nitroanilide + H2O | - |
Rattus norvegicus | succinyl-Ala-Ala-Ala-Ala + 4-nitroaniline | - |
ir | |
succinyl-Ala-Ala-Ala-Ala-Ala-4-nitroanilide + H2O | - |
Rattus norvegicus | succinyl-Ala-Ala-Ala-Ala-Ala + 4-nitroaniline | - |
ir | |
succinyl-Ala-Ala-Pro-4-nitroanilide + H2O | - |
Rattus norvegicus | succinyl-Ala-Ala-Pro + 4-nitroaniline | - |
ir | |
succinyl-Ala-Pro-Ala-4-nitroanilide + H2O | - |
Rattus norvegicus | succinyl-Ala-Pro-Ala + 4-nitroaniline | - |
ir | |
succinyl-Pro-Ala-Ala-4-nitroanilide + H2O | - |
Rattus norvegicus | succinyl-Pro-Ala-Ala + 4-nitroaniline | - |
ir |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
40 | - |
assay at | Rattus norvegicus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.004 | - |
succinyl-Ala-Ala-Pro-4-nitroanilide | - |
Rattus norvegicus | |
0.07 | - |
succinyl-Ala-Ala-4-nitroanilide | - |
Rattus norvegicus | |
0.15 | - |
succinyl-Pro-Ala-Ala-4-nitroanilide | - |
Rattus norvegicus | |
0.3 | - |
succinyl-Ala-Ala-Ala-4-nitroanilide | - |
Rattus norvegicus | |
0.8 | - |
succinyl-Ala-Ala-Ala-Ala-Ala-4-nitroanilide | - |
Rattus norvegicus | |
0.9 | - |
succinyl-Ala-Ala-Ala-Ala-4-nitroanilide | - |
Rattus norvegicus | |
5.3 | - |
benzyloxycarbonyl-Pro-Ala-Ala-Ala-Pro | - |
Rattus norvegicus | |
7.7 | - |
benzyloxycarbonyl-Pro-Ala-Ala-Ala-Pro-NH2 | - |
Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
assay at | Rattus norvegicus |