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Literature summary for 3.4.22.14 extracted from

  • Grozdanovic, M.M.; Cavic, M.; Nesic, A.; Andjelkovic, U.; Akbari, P.; Smit, J.J.; Gavrovic-Jankulovic, M.
    Kiwifruit cysteine protease actinidin compromises the intestinal barrier by disrupting tight junctions (2016), Biochim. Biophys. Acta, 1860, 516-526 .
    View publication on PubMed
Search for more literature for 3.4.22.14

Application

Application Comment Organism
medicine the enzyme increases intestinal permeability in both in vivo (mice) and in vitro (Caco-2 cell culture) models. The food allergen with intrinsic proteolytic activity can compromise the gut epithelial barrier, contributing to the sensitization process in food allergy pathogenesis Actinidia deliciosa

Organism

Organism UniProt Comment Textmining
Actinidia deliciosa A5HII1 Hayward cv
-

Purification (Commentary)

Purification (Comment) Organism
-
 Actinidia deliciosa

Source Tissue

Source Tissue Comment Organism Textmining
pulp
-
 Actinidia deliciosa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
casein + H2O
-
 Actinidia deliciosa ?
-
 ?
human occludin + H2O human occludin is fragmented, and putative Act d1 cleavage sites are identified in extracellular loops of human occludin Actinidia deliciosa ?
-
 ?

Synonyms

Synonyms Comment Organism
Actd1
-
 Actinidia deliciosa

General Information

General Information Comment Organism
additional information the enzyme increases intestinal permeability in both in vivo (mice) and in vitro (Caco-2 cell culture) models. The food allergen with intrinsic proteolytic activity can compromise the gut epithelial barrier, contributing to the sensitization process in food allergy pathogenesis Actinidia deliciosa