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Literature summary for 3.4.22.10 extracted from

  • Nelson, D.C.; Garbe, J.; Collin, M.
    Cysteine proteinase SpeB from Streptococcus pyogenes - a potent modifier of immunologically important host and bacterial proteins (2011), Biol. Chem., 392, 1077-1088.
    View publication on PubMed
Search for more literature for 3.4.22.10

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
28000
-
 x * 28000, mature enzyme Streptococcus pyogenes
40000
-
 x * 40000, proenzyme, estimated from amino acid sequence Streptococcus pyogenes

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha1-antitrypsin + H2O Streptococcus pyogenes
-
 ?
-
 ?
C5a peptidase + H2O Streptococcus pyogenes cleavage sites are APA-K, AVI-D, SGTS, and C-terminally ?
-
 ?
complement factor C3b + H2O Streptococcus pyogenes cleavage sites are RTL-D, NHK-L, LAR-S, and VEL-I ?
-
 ?
decorin + H2O Streptococcus pyogenes
-
 ?
-
 ?
EndoS + H2O Streptococcus pyogenes cleavage site is VML-K ?
-
 ?
Fba protein + H2O Streptococcus pyogenes
-
 ?
-
 ?
Fibrinogen + H2O Streptococcus pyogenes cleavage sites are C-terminally in Aalpha chains ?
-
 ?
Fibronectin + H2O Streptococcus pyogenes
-
 ?
-
 ?
H-kininogen + H2O Streptococcus pyogenes cleavage sites are LMK-R and PFR-S ?
-
 ?
human CXCL10 + H2O Streptococcus pyogenes
-
 ?
-
 ?
immunoglobulin A + H2O Streptococcus pyogenes cleavage sites are the heavy chains ?
-
 ?
immunoglobulin D + H2O Streptococcus pyogenes cleavage sites are the heavy chains ?
-
 ?
immunoglobulin E + H2O Streptococcus pyogenes cleavage sites are the heavy chains ?
-
 ?
immunoglobulin G + H2O Streptococcus pyogenes cleavage site is LLG-G in gamma-chain ?
-
 ?
immunoglobulin M + H2O Streptococcus pyogenes cleavage sites are the heavy chains ?
-
 ?
Laminin + H2O Streptococcus pyogenes
-
 ?
-
 ?
M protein + H2O Streptococcus pyogenes
-
 ?
-
 ?
additional information Streptococcus pyogenes CXCL9 is quite resistant to hydrolysis by SpeB ?
-
 ?
plasminogen + H2O Streptococcus pyogenes
-
 ?
-
 ?
pro-interleukin-1beta + H2O Streptococcus pyogenes cleavage site is YVH-D interleukin-1beta + ?
-
 ?
properdin + H2O Streptococcus pyogenes
-
 ?
-
 ?
protein F1 + H2O Streptococcus pyogenes
-
 ?
-
 ?
protein H + H2O Streptococcus pyogenes
-
 ?
-
 ?
Sda1 + H2O Streptococcus pyogenes
-
 ?
-
 ?
Slr + H2O Streptococcus pyogenes
-
 ?
-
 ?
SmeZ + H2O Streptococcus pyogenes
-
 ?
-
 ?
SpeBz + H2O Streptococcus pyogenes auto-cleavage sites are AIK-A, KVN-L, QIK-E, TYA-G, and EIK-Q mature SpeB + ?
-
 ?
streptokinase + H2O Streptococcus pyogenes
-
 ?
-
 ?
streptolysin O + H2O Streptococcus pyogenes
-
 ?
-
 ?
urokinase receptor + H2O Streptococcus pyogenes cleavage site is close to the GPI anchor ?
-
 ?
Vitronectin + H2O Streptococcus pyogenes
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus pyogenes
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha1-antitrypsin + H2O
-
 Streptococcus pyogenes ?
-
 ?
C5a peptidase + H2O cleavage sites are APA-K, AVI-D, SGTS, and C-terminally Streptococcus pyogenes ?
-
 ?
complement factor C3b + H2O cleavage sites are RTL-D, NHK-L, LAR-S, and VEL-I Streptococcus pyogenes ?
-
 ?
decorin + H2O
-
 Streptococcus pyogenes ?
-
 ?
EndoS + H2O cleavage site is VML-K Streptococcus pyogenes ?
-
 ?
Fba protein + H2O
-
 Streptococcus pyogenes ?
-
 ?
Fibrinogen + H2O cleavage sites are C-terminally in Aalpha chains Streptococcus pyogenes ?
-
 ?
Fibronectin + H2O
-
 Streptococcus pyogenes ?
-
 ?
H-kininogen + H2O cleavage sites are LMK-R and PFR-S Streptococcus pyogenes ?
-
 ?
human CXCL10 + H2O
-
 Streptococcus pyogenes ?
-
 ?
immunoglobulin A + H2O cleavage sites are the heavy chains Streptococcus pyogenes ?
-
 ?
immunoglobulin D + H2O cleavage sites are the heavy chains Streptococcus pyogenes ?
-
 ?
immunoglobulin E + H2O cleavage sites are the heavy chains Streptococcus pyogenes ?
-
 ?
immunoglobulin G + H2O cleavage site is LLG-G in gamma-chain Streptococcus pyogenes ?
-
 ?
immunoglobulin M + H2O cleavage sites are the heavy chains Streptococcus pyogenes ?
-
 ?
Laminin + H2O
-
 Streptococcus pyogenes ?
-
 ?
M protein + H2O
-
 Streptococcus pyogenes ?
-
 ?
additional information CXCL9 is quite resistant to hydrolysis by SpeB Streptococcus pyogenes ?
-
 ?
plasminogen + H2O
-
 Streptococcus pyogenes ?
-
 ?
pro-interleukin-1beta + H2O cleavage site is YVH-D Streptococcus pyogenes interleukin-1beta + ?
-
 ?
properdin + H2O
-
 Streptococcus pyogenes ?
-
 ?
protein F1 + H2O
-
 Streptococcus pyogenes ?
-
 ?
protein H + H2O
-
 Streptococcus pyogenes ?
-
 ?
Sda1 + H2O
-
 Streptococcus pyogenes ?
-
 ?
Slr + H2O
-
 Streptococcus pyogenes ?
-
 ?
SmeZ + H2O
-
 Streptococcus pyogenes ?
-
 ?
SpeBz + H2O auto-cleavage sites are AIK-A, KVN-L, QIK-E, TYA-G, and EIK-Q Streptococcus pyogenes mature SpeB + ?
-
 ?
streptokinase + H2O
-
 Streptococcus pyogenes ?
-
 ?
streptolysin O + H2O
-
 Streptococcus pyogenes ?
-
 ?
urokinase receptor + H2O cleavage site is close to the GPI anchor Streptococcus pyogenes ?
-
 ?
Vitronectin + H2O
-
 Streptococcus pyogenes ?
-
 ?

Subunits

Subunits Comment Organism
? x * 28000, mature enzyme Streptococcus pyogenes
? x * 40000, proenzyme, estimated from amino acid sequence Streptococcus pyogenes

Synonyms

Synonyms Comment Organism
SpeB
-
 Streptococcus pyogenes