Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.1 extracted from

  • Demcsak, A.; Geisz, A.; Sahin-Toth, M.
    Engineering mouse cationic trypsinogen for rapid and selective activation by cathepsin B (2019), Sci. Rep., 9, 9188 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.1

Application

Application Comment Organism
medicine engineering of a mouse T7 trypsinogen mutant (D22A,K24G), which is robustly activated by cathepsin B but cannot undergo autoactivation. These studies set the stage for the generation of a preclinical mouse model of CTSB-dependent pancreatitis Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Mus musculus 5764
-

Organism

Organism UniProt Comment Textmining
Mus musculus P10605
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
mouse T7 trypsinogen mutant D22A/K24G + H2O engineering of a mouse T7 trypsinogen mutant (D22A,K24G), which is robustly activated by cathepsin B but cannot undergo autoactivation Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
CTSB
-
 Mus musculus