Literature summary for 3.4.22.1 extracted from

Downs, C.A.; Dang, V.D.; Johnson, N.M.; Denslow, N.D.; Alli, A.A.
Hydrogen peroxide stimulates exosomal cathepsin B regulation of the receptor for advanced glycation end-products (RAGE) (2018), J. Cell. Biochem., 119, 599-606 .

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
exosome	cathepsin B activity is detected in exosomes isolated from hydrogen peroxide treated cells	Rattus norvegicus	-	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P00787	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
alveolar epithelial cell line	type 1 alveolar epithelial (R3/1) cell	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Ac-Arg-Arg-7-amido-4-trifluoromethylcoumarin + H2O	-	Rattus norvegicus	Ac-Arg-Arg + 7-amino-4-trifluoromethylcoumarin	-	?

General Information

General Information	Comment	Organism
physiological function	exosomal cathepsin B regulates the receptor for advanced glycation end-products (RAGE) in type 1 alveolar cells under conditions of oxidative stress	Rattus norvegicus

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Release 2023.1 (January 2023)