Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Danio rerio | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Danio rerio | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
cathepsin Ba | - |
Danio rerio |
General Information | Comment | Organism |
---|---|---|
physiological function | role for maternal Ctsba in dorsoventral patterning and morphogenesis. Ctsba is required in distinct developmental processes to promote epiboly progression through modulation of the YCL cytoskeleton and promotes dorsoventral axial patterning upstream of BMP signaling. The role for Ctsba in morphogenesis is complex because Ctsba has BMP-dependent functions in DV patterning and probably also convergent-extension cell movements, but it also has BMP-independent functions necessary for the cytoskeletal organization underlying epiboly. Ctsba might modulate the ECM, regulate Ints6 or transcription factors such as Pou5f3, which have similar patterning and epiboly defects, or modulate other components to regulate early morphogenesis and epiboly | Danio rerio |