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Literature summary for 3.4.22.1 extracted from

  • Langdon, Y.G.; Fuentes, R.; Zhang, H.; Abrams, E.W.; Marlow, F.L.; Mullins, M.C.
    Split top a maternal cathepsin B that regulates dorsoventral patterning and morphogenesis (2016), Development, 143, 1016-1028 .
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Danio rerio 5764
-

Organism

Organism UniProt Comment Textmining
Danio rerio
-
-
-

Synonyms

Synonyms Comment Organism
cathepsin Ba
-
Danio rerio

General Information

General Information Comment Organism
physiological function role for maternal Ctsba in dorsoventral patterning and morphogenesis. Ctsba is required in distinct developmental processes to promote epiboly progression through modulation of the YCL cytoskeleton and promotes dorsoventral axial patterning upstream of BMP signaling. The role for Ctsba in morphogenesis is complex because Ctsba has BMP-dependent functions in DV patterning and probably also convergent-extension cell movements, but it also has BMP-independent functions necessary for the cytoskeletal organization underlying epiboly. Ctsba might modulate the ECM, regulate Ints6 or transcription factors such as Pou5f3, which have similar patterning and epiboly defects, or modulate other components to regulate early morphogenesis and epiboly Danio rerio