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Literature summary for 3.4.22.1 extracted from

  • Schmitz, J.; Gilberg, E.; Loeser, R.; Bajorath, J.; Bartz, U.; Guetschow, M.
    Cathepsin B Active site mapping with peptidic substrates and inhibitors (2019), Bioorg. Med. Chem., 27, 1-15 .
    View publication on PubMed
Search for more literature for 3.4.22.1

Inhibitors

Inhibitors Comment Organism Structure
CA-030 and derivatives Homo sapiens
CA-074 and derivatives Homo sapiens
E-64
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P07858
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Abz-Ala-Phe-Arg-Ser-Ala-X-Gln-EDDnp + H2O kcat/Km for Abz-Ala-Phe-Arg-Ser-Ala-X-Gln-EDDnp, with X is Asn > Tyr, His, Leu, Trp > Ser, Phe, Pro Lys > Asp, Ala Homo sapiens Abz-Ala-Phe-Arg + Ser-Ala-X-Gln-EDDnp
-
 ?
Abz-Ala-Phe-Arg-Ser-X-Arg-Ser-Ala-Gln-EDDnp + H2O kcat/Km for Abz-Ala-Phe-Arg-Ser-X-Arg-Ser-Ala-Gln-EDDnp, with X is Asn > Trp, Tyr, Ala > Ser, Phe > His, Lys > Asp, Leu, Pro Homo sapiens Abz-Ala-Phe-Arg + Ser-X-Arg-Ser-Ala-Gln-EDDnp
-
 ?
Abz-Ala-X-Ala-Phe-Arg-Ser-Ala-Gln-EDDnp + H2O kcat/Km for Abz-Ala-X-Ala-Phe-Arg-Ser-Ala-Gln-EDDnp, with X is Leu, Tyr > Phe, Ala, Ser, Pro > His, Lys > Asn, Asp Homo sapiens Abz-Ala-X-Ala-Phe-Arg + Ser-Ala-Gln-EDDnp
-
 ?
Abz-Ala-X-Arg-Ser-Ala-Ala-Gln-EDDnp + H2O kcat/Km for Abz-Ala-X-Arg-Ser-Ala-Ala-Gln-EDDnp, with X is Phe, Leu > Arg > Ala > Pro Homo sapiens Abz-Ala-X-Arg + Ser-Ala-Ala-Gln-EDDnp
-
 ?
Abz-X-Ala-Phe-Arg-Ser-Ala-Gln-EDDnp + H2O kcat/Km for Abz-X-Ala-Phe-Arg-Ser-Ala-Gln-EDDnp, with X is Leu, Phe, Trp > Ser, Asn, Asp, Ala > Tyr, His, Lys Homo sapiens Abz-X-Ala-Phe-Arg + Ser-Ala-Gln-EDDnp
-
 ?
benzyloxycarbonyl-Phe-Arg-AMC + H2O
-
 Homo sapiens ?
-
 ?
Dnp-Gly-Phe-Arg-Trp-X-OH + H2O kcat/Km for Dnp-Gly-Phe-Arg-Trp-X-OH, with X is Phe > Tyr, Ile > Leu > Cval > Arg > Lys, Pro > Gln, Ser > Asp, Glu, Ala Homo sapiens Dnp-Gly-Phe + Arg-Trp-X-OH
-
 ?
Dnp-Gly-Phe-Arg-X-Trp-OH + H2O kcat/Km for Dnp-Gly-Phe-Arg-X-Trp-OH, with X is Phe > Ser > Leu > Ala > Ile > Tyr, Val > Gln > Lys > Gly > His, Asp > Arg > Glu Homo sapiens Dnp-Gly-Phe + Arg-X-Trp-OH
-
 ?
Dnp-Gly-Phe-X-Phe-Trp-OH + H2O kcat/Km for Dnp-Gly-Phe-X-Phe-Trp-OH, with X is Arg > Lys > Phe > Leu > Val > His, Gln > Ser > Gly Ala > Glu > Tyr > Ile, Asp Homo sapiens Dnp-Gly-Phe-X + Phe-Trp-OH
-
 ?
Dnp-Gly-X-Arg-Phe-Trp-OH + H2O kcat/Km for Dnp-Gly-X-Arg-Phe-Trp-OH, with X is Phe > Tyr > Lys > Val > Ala > Ile > Ser, Pro > His > Leu > Arg > Asp, Glu Homo sapiens Dnp-Gly-X-Arg + Phe-Trp-OH
-
 ?
additional information active site mapping with peptidic substrates and inhibitors Homo sapiens ?
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00000224
-
 pH and temperature not specified in the publication Homo sapiens CA-074
0.00000228
-
 pH and temperature not specified in the publication Homo sapiens CA-030

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
additional information
-
 Abz-Ala-Phe-Arg-Ser-Ala-X-Gln-EDDnp kcat/Km for Abz-Ala-Phe-Arg-Ser-Ala-X-Gln-EDDnp: Asn > Tyr, His, Leu, Trp > Ser, Phe, Pro Lys > Asp, Ala Homo sapiens
additional information
-
 Abz-Ala-Phe-Arg-Ser-X-Arg-Ser-Ala-Gln-EDDnp kcat/Km for Abz-Ala-Phe-Arg-Ser-X-Arg-Ser-Ala-Gln-EDDnp: Asn > Trp, Tyr, Ala > Ser, Phe > His, Lys > Asp, Leu, Pro Homo sapiens
additional information
-
 Abz-Ala-X-Arg-Ser-Ala-Ala-Gln-EDDnp kcat/Km for Abz-Ala-X-Arg-Ser-Ala-Ala-Gln-EDDnp: Phe, Leu > Arg > Ala > Pro Homo sapiens
additional information
-
 Abz-Ala-X-Ala-Phe-Arg-Ser-Ala-Gln-EDDnp kcat/Km for Abz-Ala_X-Ala-Phe-Arg-Ser-Ala-Gln-EDDnp: Leu, Tyr > Phe, Ala, Ser, Pro > His, Lys > Asn, Asp Homo sapiens
additional information
-
 Abz-X-Ala-Phe-Arg-Ser-Ala-Gln-EDDnp kcat/Km for Abz-X-Ala-Phe-Arg-Ser-Ala-Gln-EDDnp: Leu, Phe, Trp > Ser, Asn, Asp, Ala > Tyr, His, Lys Homo sapiens
additional information
-
 Dnp-Gly-Phe-Arg-Trp-X-OH kcat/Km for Dnp-Gly-Phe-Arg-Trp-X-OH: Phe > Tyr, Ile > Leu > Cval > Arg > Lys, Pro > Gln, Ser > Asp, Glu, Ala Homo sapiens
additional information
-
 Dnp-Gly-Phe-Arg-X-Trp-OH kcat/Km for Dnp-Gly-Phe-Arg-X-Trp-OH: Phe > Ser > Leu > Ala > Ile > Tyr, Val > Gln > Lys > Gly > His, Asp > Arg > Glu Homo sapiens
additional information
-
 Dnp-Gly-Phe-X-Phe-Trp-OH kcat/Km for Dnp-Gly-Phe-X-Phe-Trp-OH: Arg > Lys > Phe > Leu > Val > His, Gln > Ser > Gly Ala > Glu > Tyr > Ile, Asp Homo sapiens
additional information
-
 Dnp-Gly-X-Arg-Phe-Trp-OH kcat/Km for Dnp-Gly-X-Arg-Phe-Trp-OH: Phe > Tyr > Lys > Val > Ala > Ile > Ser, Pro > His > Leu > Arg > Asp, Glu Homo sapiens