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Literature summary for 3.4.22.1 extracted from

  • Toomey, C.B.; Cauvi, D.M.; Hamel, J.C.; Ramirez, A.E.; Pollard, K.M.
    Cathepsin B regulates the appearance and severity of mercury-induced inflammation and autoimmunity (2014), Toxicol. Sci., 142, 339-349.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
L-3-trans-(propylcarbamoyl)oxirane-2-carbonyl-L-isoleucyl-L-proline treatment with a cathepsin B inhibitor, leads to transient reduction of local induration, expression of inflammatory cytokines, and subsequent attenuation of the systemic adaptive immune response Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P07858
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 mercury-inflammation in mice is associated with a selective increase in activity of cysteine cathepsin B Mus musculus

Synonyms

Synonyms Comment Organism
cathepsin B
-
 Mus musculus

General Information

General Information Comment Organism
physiological function sensitivity to mHgIA is linked to an early cathepsin B regulated inflammatory response which is necessary for the subsequent adaptive autoimmune response leading to disease Mus musculus