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Literature summary for 3.4.22.1 extracted from

  • Balboula, A.Z.; Yamanaka, K.; Sakatani, M.; Kawahara, M.; Hegab, A.O.; Zaabel, S.M.; Takahashi, M.
    Cathepsin B activity has a crucial role in the developmental competence of bovine cumulus-oocyte complexes exposed to heat shock during in vitro maturation (2013), Reproduction, 146, 407-417.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
N-(trans-epoxysuccinyl)-L-leucine 4-guanidinobutylamide addition of E-64 significantly decreases the activities of cathepsin B and caspase 3, and TUNEL-positive cells in heat-shocked in vitro maturated (IVM) bovine cumulus-oocyte complexes. Addition of inhibitor during in vitro maturation under heat shock conditions significantly improves both developmental competence and quality of the produced embryos Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus P07688
-
-

Source Tissue

Source Tissue Comment Organism Textmining
oocyte
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
heat-shocked in vitro maturation (IVM) of bovine cumulus-oocyte complexes show significantly high activities and expressions of both cathepsin B, and caspase 3 accompanied by a significant increase in number of TUNEL-positive cells Bos taurus

Synonyms

Synonyms Comment Organism
cathepsin B
-
Bos taurus

General Information

General Information Comment Organism
physiological function present results implicate cathepsin B activity as one of the possible pathways that are responsible for heat shock-induced apoptosis in bovine cumulus-oocyte complexes Bos taurus