Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CysC | natural inhibitor of CatB. CysC deletion in knockout mice leads to an enhanced CatB activity | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid-beta + H2O | Mus musculus | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid-beta + H2O | - |
Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CatB | - |
Mus musculus |
cathepsin B | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | CysC deletion in knockout mice leads to an enhanced CatB activity | Mus musculus |
malfunction | enhancing CatB activity by CysC deletion significantly lowers total amyloid-betaand amyloid-beta42 levels in human amyloid precursor protein wild-type mice, whereas CatB deletion increases amyloidbeta levels | Mus musculus |
malfunction | transgenic mice are generated overexpressing CatB under the control of a neuron-specific enolase promoter: Enhancing neuronal CatB activity in human amyloid precursor protein wild-type mice significantly lowers amyloidbeta42 levels | Mus musculus |