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Literature summary for 3.4.22.1 extracted from

  • Raghav, N.; Singh, M.
    Acyl hydrazides and triazoles as novel inhibitors of mammalian cathepsin B and cathepsin H (2014), Eur. J. Med. Chem., 77, 231-242.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-chlorobenzohydrazide competitive inhibition Capra hircus
2-methoxybenzohydrazide competitive inhibition Capra hircus
3,5-diphenyl-4-amino-1,2,4-triazole non-competitive inhibition Capra hircus
3-(2-hydroxy-3-methylphenyl)-5-(2-hydroxy-3-methylphenyl)-4-amino-1,2,4-triazole non-competitive inhibition Capra hircus
3-(2-methylphenyl)-5-(2-methylphenyl)-4-amino-1,2,4-triazole non-competitive inhibition Capra hircus
3-(3-aminophenyl)-5-(3-aminophenyl)-4-amino-1,2,4-triazole non-competitive inhibition Capra hircus
3-(3-methylphenyl)-5-(3-methylphenyl)-4-amino-1,2,4-triazole non-competitive inhibition Capra hircus
3-(4-chlorophenyl)-5-(4-chlorophenyl)-4-amino-1,2,4-triazole non-competitive inhibition Capra hircus
3-(4-methylphenyl)-5-(4-methylphenyl)-4-amino-1,2,4-triazole non-competitive inhibition Capra hircus
3-phenyl-5-(3-nitrophenyl)-4-amino-1,2,4-triazole non-competitive inhibition Capra hircus
3-phenyl-5-(4-nitrophenyl)-4-amino-1,2,4-triazole non-competitive inhibition Capra hircus
4-hydroxybenzohydrazide competitive inhibition Capra hircus
4-methoxybenzohydrazide competitive inhibition Capra hircus
phenylacetyl hydrazine competitive inhibition Capra hircus

Organism

Organism UniProt Comment Textmining
Capra hircus H9B8T9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Capra hircus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.01038
-
pH 5, 37°C Capra hircus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-benzoyl-L-Arg-2-naphthylamide + H2O
-
Capra hircus N-benzoyl-L-Arg + 2-naphthylamine
-
?

Synonyms

Synonyms Comment Organism
cathepsin B
-
Capra hircus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Capra hircus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
assay at Capra hircus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00064
-
4-methoxybenzohydrazide pH 5, 37°C Capra hircus
0.00087
-
phenylacetyl hydrazine pH 5, 37°C Capra hircus
0.00095
-
3-(3-aminophenyl)-5-(3-aminophenyl)-4-amino-1,2,4-triazole pH 5, 37°C Capra hircus
0.00136
-
2-chlorobenzohydrazide pH 5, 37°C Capra hircus
0.00143
-
3-phenyl-5-(3-nitrophenyl)-4-amino-1,2,4-triazole pH 5, 37°C Capra hircus
0.0019
-
4-hydroxybenzohydrazide pH 5, 37°C Capra hircus
0.0024
-
3-(4-chlorophenyl)-5-(4-chlorophenyl)-4-amino-1,2,4-triazole pH 5, 37°C Capra hircus
0.0032
-
3-(2-hydroxy-3-methylphenyl)-5-(2-hydroxy-3-methylphenyl)-4-amino-1,2,4-triazole pH 5, 37°C Capra hircus
0.0048
-
3-phenyl-5-(4-nitrophenyl)-4-amino-1,2,4-triazole pH 5, 37°C Capra hircus
0.008
-
3-(4-methylphenyl)-5-(4-methylphenyl)-4-amino-1,2,4-triazole pH 5, 37°C Capra hircus
0.0127
-
2-methoxybenzohydrazide pH 5, 37°C Capra hircus
0.0149
-
3-(2-methylphenyl)-5-(2-methylphenyl)-4-amino-1,2,4-triazole pH 5, 37°C Capra hircus
0.0385
-
3-(3-methylphenyl)-5-(3-methylphenyl)-4-amino-1,2,4-triazole pH 5, 37°C Capra hircus
0.1205
-
3,5-diphenyl-4-amino-1,2,4-triazole pH 5, 37°C Capra hircus