Literature summary for 3.4.22.1 extracted from

Murata, R.M.; Yatsuda, R.; dos Santos, M.H.; Kohn, L.K.; Martins, F.T.; Nagem, T.J.; Alencar, S.M.; de Carvalho, J.E.; Rosalen, P.L.
Antiproliferative effect of benzophenones and their influence on cathepsin activity (2010), Phytother. Res., 24, 379-383.

Search for more literature for 3.4.22.1

Activating Compound

Activating Compound	Comment	Organism	Structure
DTT	-	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
7-epiclusianone	a prenylated benzophenone isolated from pericarp hexane extract of dried fruits of Rheedia brasiliensis	Homo sapiens
doxorubicin	-	Homo sapiens
garciniaphenone	a prenylated benzophenone isolated from pericarp hexane extract of dried fruits of Rheedia brasiliensis	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
lysosome	-	Homo sapiens	5764	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MCF-7 cell	a breast cancer cell line	Homo sapiens	-
NCI-H460 cell	a lung non-small cell cancer cell line	Homo sapiens	-
NCI/ADR cell	a drug-resistant breast cancer cell line	Homo sapiens	-
OVCAR-3 cell	an ovarian cancer cell line	Homo sapiens	-
PC-3 cell	a prostate cancer cell line	Homo sapiens	-
RCC 786-O cell	a kidney cancer cell line	Homo sapiens	-
SCC-15 cell	a tongue cancer cell line	Homo sapiens	-
SCC-4 cell	a tongue cancer cell line	Homo sapiens	-
UACC-62 cell	a melanoma cell line	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide + H2O	-	Homo sapiens	N-benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
25	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
additional information	-	IC50 values for cell proliferation of prenylated benzophenones from Rheedia brasiliensis, overview	Homo sapiens	additional information

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Release 2023.1 (January 2023)