Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | p53-dependent lysosomal destabilization and cathepsin B activation contribute for increased sensitivity of p21-deficient cells to embelin with enhanced caspase 9 and caspase 3 activation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CA-074-Me | in vivo inhibition | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HCT-116 cell | a colon adenocarcinoma cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | N-benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | lysosomal destabilization contributes for cell death through controlled release of lysosomal enzymes, the prominent among them being cathepsin B. p53-dependent lysosomal destabilization and cathepsin B activation contribute for increased sensitivity of p21-deficient cells to embelin with enhanced caspase 9 and caspase 3 activation, overview | Homo sapiens |