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Literature summary for 3.4.22.1 extracted from

  • Ahn, J.E.; Guarino, L.A.; Zhu-Salzman, K.
    Coordination of hepatocyte nuclear factor 4 and seven-up controls insect counter-defense cathepsin B expression (2010), J. Biol. Chem., 285, 6573-6584.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.1

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition of CatB by soybean cysteine protease inhibitor Callosobruchus maculatus

Organism

Organism UniProt Comment Textmining
Callosobruchus maculatus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
alimentary canal
-
 Callosobruchus maculatus
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hepatopancreas
-
 Callosobruchus maculatus
-

Synonyms

Synonyms Comment Organism
CatB
-
 Callosobruchus maculatus
cathepsin B-type cysteine protease
-
 Callosobruchus maculatus

Expression

Organism Comment Expression
Callosobruchus maculatus Seven-up, Svp, is a transcriptional repressor of CatB, predominantly expressed in unadapted insect midgut. A CmCatB promoter region containing two tandem chicken ovalbumin upstream promoter, COUP, sites, is the cis-element for Seven-up. CmSvp inhibits CmHNF-4-mediated transcriptional activation even in the absence of its DNA-binding domain down
Callosobruchus maculatus hepatocyte nuclear factor 4, HNF-4, more abundant in adapted bruchids. It upregulates the enzyme in the digestive tract of scN-adapted bruchids, it binds to a CmCatB promoter region containing two tandem chicken ovalbumin upstream promoter, COUP, sites, which is also the cis-element for Seven-up, Svp, a transcriptional repressor of CatB. CmSvp inhibits CmHNF-4-mediated transcriptional activation even in the absence of its DNA-binding domain up

General Information

General Information Comment Organism
additional information coordination between transcription factors CmHNF-4 and CmSvp is important in counter-defense gene regulation in insects, overview Callosobruchus maculatus
physiological function CmCatB has a unique role in insect adaptation to the effect of dietary scN. Cowpea bruchids dramatically induce CmCatB expression when major digestive proteases are inactivated by dietary scN, which is presumably an adaptive strategy that insects use to minimize effects of nutrient deficiency Callosobruchus maculatus