Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.22.1 extracted from

  • Reich, M.; Wieczerzak, E.; Jankowska, E.; Palesch, D.; Boehm, B.O.; Burster, T.
    Specific cathepsin B inhibitor is cell-permeable and activates presentation of TTC in primary human dendritic cells (2009), Immunol. Lett., 123, 155-159.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
CA-074-OMe blocks cysteine cathepsins in addition to CatB in in primary human antigen-presenting cells Homo sapiens
Z-Arg-Leu-Arg-alpha-aza-glycyl-Ile-Val-OMe i.e. ZRLR, a highly selective cathepsin B inhibitor, cell-permeable, almost complete inhibition at 0.0001 mM Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte primary Homo sapiens
-
dendritic cell primary Homo sapiens
-
mononuclear cell from peripheral blood Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-benzyloxycarbonyl-Arg-Arg-4-methyl-7-amidocoumarin + H2O
-
Homo sapiens N-benzyloxycarbonyl-Arg-Arg + 4-methyl-7-aminocoumarin
-
?

Synonyms

Synonyms Comment Organism
CatB
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
assay at room temperature Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
assay at Homo sapiens