Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CID 647501 | - |
Homo sapiens | |
CID 653297 | - |
Homo sapiens | |
CID 66541 | - |
Homo sapiens | |
additional information | screening of pyrimidotriazine-diones and pyrazole sulfonamides as cathepsin B inhibitors, structure-function relationship, overview. Pyrimidotriazine-dione inhibitors, along with several structurally unrelated compounds, are inactive in presence of the reductant cysteine or DTT, thus the inhibitors are acting through a DTT-dependent redox cycling mechanism, rather than through direct inhibition of the enzyme | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the assay uses a modified aminomethylcoumarin dipeptide substrate, which generates a fluorescent signal upon cleavage by cathepsin B | Homo sapiens | ? | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000046 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | CID 66541 | |
0.000071 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | CID 647501 | |
0.000072 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | CID 653297 |