Inhibitors | Comment | Organism | Structure |
---|---|---|---|
benzylamido-L-trans-epoxysuccinyl-Ile-O-benzyl ester | - |
Homo sapiens | |
benzylamido-L-trans-epoxysuccinyl-Ile-Pro-OH | - |
Homo sapiens | |
CA-074-Me | i.e. propylcarbonyl-L-trans-epoxysuccinyl-Ile-Pro-OH, enzyme binding structure at the active site cleft, modelling, overview | Homo sapiens | |
CA030 | i.e. ethoxy-L-trans-epoxysuccinyl-Ile-Pro-OH | Homo sapiens | |
E64c | the (2S,3S)-3-(L-[N-(3-methylbutyl)amino]leucyl) side chain binds at the S1 and S3 subsites | Homo sapiens | |
ethoxy-L-trans-epoxysuccinyl-Gly-Pro-OH | - |
Homo sapiens | |
ethoxy-L-trans-epoxysuccinyl-Ile-Ala-OH | - |
Homo sapiens | |
ethoxy-L-trans-epoxysuccinyl-Ile-Ile-OH | - |
Homo sapiens | |
ethoxy-L-trans-epoxysuccinyl-Ile-OH | - |
Homo sapiens | |
ethoxy-L-trans-epoxysuccinyl-Thr-Ile-OH | - |
Homo sapiens | |
additional information | development of cathepsin inhibitors and structure-based design of cathepsin B-specific inhibitor, binding mode at the active site and structure-activity relationship, overview. Quantitative assesment of inhibitor binding at the SN-site of cathepsin B, overview | Homo sapiens | |
propylcarbonyl-L-trans-epoxysuccinyl-Ile-O-benzyl ester | - |
Homo sapiens | |
propylcarbonyl-L-trans-epoxysuccinyl-Ile-Pro-O-methyl ester | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-/- bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides | cathepsin B possesses a long and narrow substrate-binding active site cleft with catalytic residue Cys, the surfaces of the S1 and S1' subsites are negatively charged due to presence of Glu122 and Glu194, the occluding loop of residue 105-125 is a structural feature containing the two positively charged His residues, His110 and His111, overview | Homo sapiens |
Subunits | Comment | Organism |
---|---|---|
More | three-dimensional structure of cathepsin B in comparison to other cathepsins, it possesses a long and narrow substrate-binding active site cleft with catalytic residue Cys, the surfaces of the S1 and S1' subsites are negatively charged due to presence of Glu122 and Glu194, the occluding loop of residue 105-125 is a structural feature containing the two positively charged His residues, His110 and His111, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
More | cathepsin B belongs to the lysosomal cysteine protease subgroup of the cathepsin family | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000023 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | ethoxy-L-trans-epoxysuccinyl-Ile-Ala-OH | |
0.000024 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | ethoxy-L-trans-epoxysuccinyl-Ile-Ile-OH | |
0.000029 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | benzylamido-L-trans-epoxysuccinyl-Ile-Pro-OH | |
0.000038 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | CA-074-Me | |
0.00012 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | CA030 | |
0.00041 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | ethoxy-L-trans-epoxysuccinyl-Thr-Ile-OH | |
0.0091 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | propylcarbonyl-L-trans-epoxysuccinyl-Ile-O-benzyl ester | |
0.0153 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | ethoxy-L-trans-epoxysuccinyl-Gly-Pro-OH | |
0.024 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | ethoxy-L-trans-epoxysuccinyl-Ile-OH | |
0.046 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | benzylamido-L-trans-epoxysuccinyl-Ile-O-benzyl ester | |
0.068 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | propylcarbonyl-L-trans-epoxysuccinyl-Ile-Pro-O-methyl ester |
General Information | Comment | Organism |
---|---|---|
malfunction | cathepsin B is a major lysosomal protease, its overactivation is involved in muscular dystrophy, bone resorption, pulmonary emphysem, and tumor metastasis | Homo sapiens |