Protein Variants | Comment | Organism |
---|---|---|
additional information | CTB knockout MEF cells are partially resistant to apoptosis induced by etoposide and IL-3 deprivation, but cannot be rescued from cell death in contrast to wild-type cells | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Mus musculus | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Mus musculus | - |
monocyte | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
CTB | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | apoptotic stimuli, e.g. exposure to etoposide, ultraviolet light, FasL or deprivation of interleukin-3, trigger lysosomal membrane permeability, leading to the release of cathepsins, dependent on Bax/Bak and components of the apoptosome, which activate death signaling pathways in the cytosol, overview. Cathepsin B does not contribute to the commitment step of apoptosis, as Bax and Bak do, but enhances the efficiency of apoptosis through an amplification loop | Mus musculus |