Application | Comment | Organism |
---|---|---|
drug development | cathepsin B is a target for development of efficient and specific inhibitors | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E)-3-chloro-1-phenyl-2-(trichloro-lambda4-tellanyl)prop-2-en-1-ol | - |
Homo sapiens | |
(2Z)-1,3-bis(2-methoxyphenyl)-4-(trichloro-lambda4-tellanyl)but-2-en-1-one | - |
Homo sapiens | |
(2Z)-1,3-bis(4-ethoxyphenyl)-4-(trichloro-lambda4-tellanyl)but-2-en-1-one | - |
Homo sapiens | |
(2Z)-1,3-bis(4-methoxyphenyl)-4-(trichloro-lambda4-tellanyl)but-2-en-1-one | - |
Homo sapiens | |
(2Z)-1,3-diphenyl-4-(trichloro-llambda4-tellanyl)but-2-en-1-one | - |
Homo sapiens | |
(3E)-2-bromo-3-(bromomethylidene)-2-(4-methoxyphenyl)-1-oxa-2l4-telluraspiro[3.5]nonane | - |
Homo sapiens | |
(3E)-2-chloro-3-(chloromethylidene)-2-(4-methoxyphenyl)-1-oxa-2l4-telluraspiro[3.5]nonane | - |
Homo sapiens | |
(3E)-4-chloro-3-[dichloro(4-methoxyphenyl)-l4-tellanyl]-2-methylbut-3-en-2-ol | - |
Homo sapiens | |
1,1,3-trichloro-2,4,5,6-tetrahydro-1H-1-benzotellurophene | - |
Homo sapiens | |
1-(dichloro[(1E)-1-chloro-3-methoxyprop-1-en-2-yl]-l4-tellanyl)-4-methoxybenzene | - |
Homo sapiens | |
1-(dichloro[(Z)-2-chloro-2-phenylethenyl]-l4-tellanyl)-4-methoxybenzene | bis-vinylic organotellurane, can be a candidate as a starting compound to design more efficient and specific inhibitors for cathepsin B | Homo sapiens | |
2-[(6-([3'-(aminomethyl)biphenyl-3-yl]oxy)-3,5-difluoropyridin-2-yl)oxy]benzoic acid | - |
Homo sapiens | |
ammonium 1-tribromo-1,3,2-dioxatellurolane | - |
Homo sapiens | |
ammonium 1-trichloro-1,3,2-dioxatellurolane | - |
Homo sapiens | |
additional information | design and synthesis of hypervalent tellurium compounds, and irreversible inhibition of cathepsins B by hypervalent tellurium compounds, e.g. organotellurium(IV) compounds, i.e. organotelluranes, that react with thiols forming mixed dichalcogenides, with a tellurium-sulfur bond. Mechanisms for two- and one-step irreversible enzyme inhibition, overview | Homo sapiens | |
N-benzyl-N,N-diethylethanaminium 1-trichloro-4-chloro-2,3-dihydro-2-oxatellurophene | - |
Homo sapiens | |
trichloro(dioxoethylene-O,O')tellurate | - |
Homo sapiens | |
[N-benzyl-N,N-diethylethanaminium]2 hexachloro-lambda6-tellane | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | second-order inactivation rate constants for cathepsin B, overview | Homo sapiens | |
0.0127 | - |
ammonium 1-trichloro-1,3,2-dioxatellurolane | pH 6.5, 25°C | Homo sapiens | |
0.0302 | - |
ammonium 1-tribromo-1,3,2-dioxatellurolane | pH 6.5, 25°C | Homo sapiens | |
0.1675 | - |
[N-benzyl-N,N-diethylethanaminium]2 hexachloro-lambda6-tellane | pH 6.5, 25°C | Homo sapiens |