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Literature summary for 3.4.22.1 extracted from

  • Li, J.H.; DAlessio, A.; Pober, J.S.
    Lipopolysaccharide can trigger a cathepsin B-dependent programmed death response in human endothelial cells (2009), Am. J. Pathol., 175, 1124-1135.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.1

Activating Compound

Activating Compound Comment Organism Structure
lipopolysaccharide activates a Cat-B-dependent programmed death response in endothelial cells that is independent of both myeloid differentiation factor 88 and Toll-like receptor-associated interferon-inducing factor, is blocked by both Fas-associated death domain protein and phosphatidylinositol 3 kinase. Activates both caspase- and Cat B-dependent death pathways in presence of phosphatidylinositol 3 kinase inhibitor LY294002 or the inflammatory cytokine interferon-gamma Homo sapiens
additional information knockdown of cellular FLICE inhibitory protein potentiates the caspase-dependent pathway but does not activate the Cat B-dependent death response. Also knockdown of either myeloid differentiation factor 88 or Toll-like receptor-associated interferon-inducing factor expression does not affect the LPS-triggered Cat B death response in Fas-associated death domain protein-deficient human umbilical vein endothelial cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
CA-074-Me Cat B-selective inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell human umbilical vein endothelial cells, HUVECs Homo sapiens
-
umbilical vein human umbilical vein endothelial cells, HUVECs Homo sapiens
-

Synonyms

Synonyms Comment Organism
cat B
-
 Homo sapiens

General Information

General Information Comment Organism
additional information based on the use of proteinase inhibitors, cell death changes from being principally caspase-dependent to being principally cathepsin B-dependent, overview Homo sapiens