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Literature summary for 3.4.22.1 extracted from

  • Geraghty, P.; Rogan, M.P.; Greene, C.M.; Brantly, M.L.; ONeill, S.J.; Taggart, C.C.; McElvaney, N.G.
    Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro (2008), Thorax, 63, 621-626.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information neutrophil elastase induces expression of cathepsin B in vivo and in vitro Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
CA-074 a cathepsin B inhibitor Homo sapiens
additional information alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B in vivo and in vitro Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular e.g. secreted from monocytes and macrophages Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens increased cathepsin B levels in acute and chronic lung diseases resulting from high levels of extracellular neutrophil elastase, expression of the protease can be inhibited by alpha1-antitrypsin augmentation therapy ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bronchoalveolar lavage fluid from patients with alpha1-antitrypsin deficiency, pneumonia and healthy individuals Homo sapiens
-
U-937 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carbobenzoxy-Arg-Arg-7-amido-4-methylcoumarin + H2O
-
Homo sapiens carbobenzoxy-Arg-Arg + 7-amino-4-methylcoumarin
-
?
Gelatin + H2O
-
Homo sapiens ?
-
?
additional information increased cathepsin B levels in acute and chronic lung diseases resulting from high levels of extracellular neutrophil elastase, expression of the protease can be inhibited by alpha1-antitrypsin augmentation therapy Homo sapiens ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
assay at Homo sapiens