Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | neutrophil elastase induces expression of cathepsin B in vivo and in vitro | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CA-074 | a cathepsin B inhibitor | Homo sapiens | |
additional information | alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B in vivo and in vitro | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | e.g. secreted from monocytes and macrophages | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | increased cathepsin B levels in acute and chronic lung diseases resulting from high levels of extracellular neutrophil elastase, expression of the protease can be inhibited by alpha1-antitrypsin augmentation therapy | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bronchoalveolar lavage fluid | from patients with alpha1-antitrypsin deficiency, pneumonia and healthy individuals | Homo sapiens | - |
U-937 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
carbobenzoxy-Arg-Arg-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | carbobenzoxy-Arg-Arg + 7-amino-4-methylcoumarin | - |
? | |
Gelatin + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | increased cathepsin B levels in acute and chronic lung diseases resulting from high levels of extracellular neutrophil elastase, expression of the protease can be inhibited by alpha1-antitrypsin augmentation therapy | Homo sapiens | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | - |
assay at | Homo sapiens |