Literature summary for 3.4.22.1 extracted from

Fricker, S.P.; Mosi, R.M.; Cameron, B.R.; Baird, I.; Zhu, Y.; Anastassov, V.; Cox, J.; Doyle, P.S.; Hansell, E.; Lau, G.; Langille, J.; Olsen, M.; Qin, L.; Skerlj, R.; Wong, R.S.; Santucci, Z.; McKerrow, J.H.
Metal compounds for the treatment of parasitic diseases (2008), J. Inorg. Biochem., 102, 1839-1845.

Search for more literature for 3.4.22.1

Inhibitors

Inhibitors	Comment	Organism	Structure
(2(1H)-pyridinethionato-kappaS2)[2,6-bis[(mercapto-kappaS)methyl]pyridine-kappaN] oxorhenium(V)	-	Homo sapiens
(acetato)(isopropylamine)(2-((2dimethylamino)-methyl)phenyl)Pd(II)	-	Homo sapiens
(chloro)(isopropylamine)(2-((2dimethylamino)methyl)phenyl)Pd(II)	-	Homo sapiens
(chloro)(pryidinyl)(2-((2dimethylamino)methyl)phenyl)Pd(II)	-	Homo sapiens
(chloro)[2,6-bis[(mercapto-kappaS)methyl]pyridine-kappaN1] oxorhenium(V)	-	Homo sapiens
(methanethiolato)[2,2'-(thio-kappaS)bis[ethanethiolato-kappaS]] oxorhenium(V)	-	Homo sapiens
(p-methoxyphenylthiolato-S)[2,2'-(thio-kappaS)bis[ethanethiolato-kappaS]] oxorhenium(V)	-	Homo sapiens
(p-methoxyphenylthiolato-S)[2,6-bis[(mercapto-kappaS)methyl]pyridine-kappaN] oxorhenium(V)	-	Homo sapiens
aceto[2,6-bis[(butylthio-kappaS)methyl]phenyl-kappaC]-,(SP-4-3)Pd(II)	-	Homo sapiens
aceto[2,6-bis[(methylthio-kappaS)methyl]phenyl-kappaC]-,(SP-4-3)Pd(II)	-	Homo sapiens
aceto[2,6-bis[(phenylthio-kappaS)methyl]phenyl-kappaC]-, (SP-4-3)Pd(II)	-	Homo sapiens
chloro-[2,2'-(thio-kappaS)bis[ethanethiolato-kappaS]] oxorhenium(V)	-	Homo sapiens
diacetato(2-((2dimethylamino)methyl)phenyl)-Au(III)	-	Homo sapiens
diaceto[2-[(2-pyridinyl-kappaN)methyl]-phenyl-kappaC]Au(III)- (SP-4-3)	-	Homo sapiens
dichloro(2-((2dimethylamino)methyl)phenyl)Au(III)	-	Homo sapiens
dichloro[2-[(2-pyridinyl-kappaN)methyl]phenyl-kappaC]Au(III)	-	Homo sapiens
malonato(2-((2dimethylamino)methyl)phenyl)Au(III)	-	Homo sapiens
[2-(mercapto-kappaS)benzoato(2-)-kappaO][2-[(2-pyridinyl-kappaN)methyl]phenyl-kappaC]Au(III)	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Z-Arg-Arg-p-nitroanilide + H2O	1 microM, pH 6.0, 10 nanoM cathepsin B	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
cathepsin B	-	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6	-	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0000088	-	-	Homo sapiens	chloro-[2,2'-(thio-kappaS)bis[ethanethiolato-kappaS]] oxorhenium(V)
0.00012	-	-	Homo sapiens	(2(1H)-pyridinethionato-kappaS2)[2,6-bis[(mercapto-kappaS)methyl]pyridine-kappaN] oxorhenium(V)
0.00018	-	-	Homo sapiens	[2-(mercapto-kappaS)benzoato(2-)-kappaO][2-[(2-pyridinyl-kappaN)methyl]phenyl-kappaC]Au(III)
0.0004	-	-	Homo sapiens	aceto[2,6-bis[(butylthio-kappaS)methyl]phenyl-kappaC]-,(SP-4-3)Pd(II)
0.0006	-	-	Homo sapiens	diacetato(2-((2dimethylamino)methyl)phenyl)-Au(III)
0.00061	-	-	Homo sapiens	malonato(2-((2dimethylamino)methyl)phenyl)Au(III)
0.00085	-	-	Homo sapiens	dichloro[2-[(2-pyridinyl-kappaN)methyl]phenyl-kappaC]Au(III)
0.0009	-	-	Homo sapiens	(chloro)[2,6-bis[(mercapto-kappaS)methyl]pyridine-kappaN1] oxorhenium(V)
0.00126	-	-	Homo sapiens	(methanethiolato)[2,2'-(thio-kappaS)bis[ethanethiolato-kappaS]] oxorhenium(V)
0.00129	-	-	Homo sapiens	diaceto[2-[(2-pyridinyl-kappaN)methyl]-phenyl-kappaC]Au(III)- (SP-4-3)
0.00136	-	-	Homo sapiens	dichloro(2-((2dimethylamino)methyl)phenyl)Au(III)
0.00152	-	-	Homo sapiens	(chloro)(pryidinyl)(2-((2dimethylamino)methyl)phenyl)Pd(II)
0.00171	-	-	Homo sapiens	(chloro)(isopropylamine)(2-((2dimethylamino)methyl)phenyl)Pd(II)
0.00274	-	-	Homo sapiens	aceto[2,6-bis[(phenylthio-kappaS)methyl]phenyl-kappaC]-, (SP-4-3)Pd(II)
0.005	-	-	Homo sapiens	(acetato)(isopropylamine)(2-((2dimethylamino)-methyl)phenyl)Pd(II)
0.00651	-	-	Homo sapiens	(p-methoxyphenylthiolato-S)[2,6-bis[(mercapto-kappaS)methyl]pyridine-kappaN] oxorhenium(V)
0.01346	-	-	Homo sapiens	aceto[2,6-bis[(methylthio-kappaS)methyl]phenyl-kappaC]-,(SP-4-3)Pd(II)
0.0886	-	-	Homo sapiens	(p-methoxyphenylthiolato-S)[2,2'-(thio-kappaS)bis[ethanethiolato-kappaS]] oxorhenium(V)

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Release 2023.1 (January 2023)