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Literature summary for 3.4.22.1 extracted from

  • Yamaguchi, T.; Naruishi, K.; Arai, H.; Nishimura, F.; Takashiba, S.
    IL-6/sIL-6R enhances cathepsin B and L production via caveolin-1-mediated JNK-AP-1 pathway in human gingival fibroblasts (2008), J. Cell. Physiol., 217, 423-432.
    View publication on PubMed
Search for more literature for 3.4.22.1

Activating Compound

Activating Compound Comment Organism Structure
interleukin-6 IL-6, in the presence of soluble form of IL-6 receptor, sIL-6R, enhances cathepsin B expression and activity via the Cav-1-JNK-AP-1 pathway in fibroblasts of the gingiva Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
CA-074Me a specific inhibitor for cathepsin B Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens regulation of cathepsin B in gingival fibroblasts involves interleukin-6 and its receptor along with the Cav-1-JNK-AP-1 pathway, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast gingival Homo sapiens
-
gingiva
-
 Homo sapiens
-
additional information JNK inhibition, but not p44/42 MAPK inhibition, significantly diminishes interleukin-6/soluble form of IL-6 receptor-induced cathepsin B production Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carbobenzoxy-Phe-Ala-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens carbobenzoxy-Phe-Ala-Arg + 7-amino-4-methylcoumarin
-
 ?
carbobenzoxy-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens carbobenzoxy-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?
additional information regulation of cathepsin B in gingival fibroblasts involves interleukin-6 and its receptor along with the Cav-1-JNK-AP-1 pathway, overview Homo sapiens ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.2
-
 assay at Homo sapiens