Application | Comment | Organism |
---|---|---|
diagnostics | increased cathepsin-B expression is predictive of more aggressive tumour behaviour over time and can be regarded as an unfavourable and independent tumour marker for endometrial cancer patients with a long follow-up | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endosome | cathepsin B is synthesised as a pre-pro-enzyme and the primary pathways for its normal trafficking to the lysosome utilise mannose-6-phosphate receptors. Inactive pro-cathepsin-B is processed to active single and double chain forms of cathepsin-B in the late endosomes and lysosomes, respectively | Homo sapiens | 5768 | - |
extracellular | under certain conditions cathepsin-B may be secreted extracellularly as a pro-enzyme that requires proteolytic activation | Homo sapiens | - |
- |
lysosome | cathepsin B is synthesised as a pre-pro-enzyme and the primary pathways for its normal trafficking to the lysosome utilise mannose-6-phosphate receptors. Inactive pro-cathepsin-B is processed to active single and double chain forms of cathepsin-B in the late endosomes and lysosomes, respectively | Homo sapiens | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | cathepsin-B is a lysosomal cysteine proteasewith broad substrate specificity, which belongs to a family of 11 cysteine proteases. The enzyme is involved in tumor progression, e.g. of endometrial carcinomas | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | cathepsin B is synthesised as a pre-pro-enzyme and the primary pathways for its normal trafficking to the lysosome utilise mannose-6-phosphate receptors. Inactive pro-cathepsin-B is processed to active single and double chain forms of cathepsin-B in the late endosomes and lysosomes, respectively. Under certain conditions cathepsin-B may be secreted extracellularly as a pro-enzyme that requires proteolytic activation | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endometrial cancer cell line | endometrial glands and epithelial cells, and also stroma | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | cathepsin-B is a lysosomal cysteine proteasewith broad substrate specificity, which belongs to a family of 11 cysteine proteases. The enzyme is involved in tumor progression, e.g. of endometrial carcinomas | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cathepsin-B | - |
Homo sapiens |