Application | Comment | Organism |
---|---|---|
diagnostics | CATB is a potent and independent prognostic marker for resectable pancreatic adenocarcinoma | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
quantitative expression analysis of CATB | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-(L-3-trans-propylcarbonyl-oxirane-2-carbonyl)-L-isoleucyl-L-proline methyl ester | i.e. CA074Me, inhibits the enzyme and PANC-1 cellular invasiveness, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | cathepsin B is a target of Hedgehog signaling in pancreatic cancer, downregulation of CATB by Hedgehog, cyclopamine reduces CATB protein and mRNA levels. CATB might influence pancreatic cancer cell invasiveness | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P07858 | gene CATB or CTSB | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
PANC-1 cell | expresses Sonic Hedgehog | Homo sapiens | - |
pancreatic cancer cell | from pancreatic ductal adenocarcinoma tissue | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | cathepsin B is a target of Hedgehog signaling in pancreatic cancer, downregulation of CATB by Hedgehog, cyclopamine reduces CATB protein and mRNA levels. CATB might influence pancreatic cancer cell invasiveness | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CatB | - |
Homo sapiens |