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Literature summary for 3.4.22.1 extracted from

  • Vreemann, A.; Qu, H.; Mayer, K.; Andersen, L.B.; Stefana, M.I.; Wehner, S.; Lysson, M.; Farcas, A.M.; Peters, C.; Reinheckel, T.; Kalff, J.; Brix, K.
    Cathepsin B release from rodent intestine mucosa due to mechanical injury results in extracellular matrix damage in early post-traumatic phases (2009), Biol. Chem., 390, 481-492.
    View publication on PubMed
Search for more literature for 3.4.22.1

Protein Variants

Protein Variants Comment Organism
additional information expression of collagen IV is up-regulated in the intestine of cathepsin B-deficient mice Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
CA-074 cathepsin B-specific inhibitor Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular release from intestine mucosa after mechanical injury and during initial post-traumatic stages Mus musculus
-
-
lysosome cathepsin B is an endo-lysosomal cysteine protease Mus musculus 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Collagen IV + H2O Mus musculus collagen IV of the basement membrane damaged by cathepsin B, that is released after mechanical injury, during initial post-traumatic stages, overview ?
-
 ?
Laminin + H2O Mus musculus laminin of the basement membrane damaged by cathepsin B, that is released after mechanical injury, during initial post-traumatic stages, overview ?
-
 ?
additional information Mus musculus the enzyme has a principle function in gross protein degradation of internalized proteins within endo-lysosomes, but cathepsins are also involved in the processing of precursor proteins to biologically active peptides in endosomes of entero-endocrine cells. Cathepsin B, released form intestinal mucosa due to mechanical injury, plays an important role in extracellular matrix damage and the onset of postoperative ileus, an inevitable consequence of abdominal surgery, in that it contributes to disintegration of the basement membrane of the gastrointestinal tract in early post-traumatic phases. Cathepsin B is best known for its critical contribution to enhanced tumor cell invasion and metastasis, including colorectal carcinomas, by degradation of extracellular matrix components ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
enterocyte at the basal poles of enterocytes facing the lamina propria Mus musculus
-
epithelial cell
-
 Mus musculus
-
gut
-
 Mus musculus
-
ileum
-
 Mus musculus
-
intestine mucosa and muscle, cathepsin B is abundantly expressed in endocytic compartments of all cells of the intestine Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Collagen IV + H2O
-
 Mus musculus ?
-
 ?
Collagen IV + H2O collagen IV of the basement membrane damaged by cathepsin B, that is released after mechanical injury, during initial post-traumatic stages, overview Mus musculus ?
-
 ?
Laminin + H2O
-
 Mus musculus ?
-
 ?
Laminin + H2O laminin of the basement membrane damaged by cathepsin B, that is released after mechanical injury, during initial post-traumatic stages, overview Mus musculus ?
-
 ?
additional information the enzyme has a principle function in gross protein degradation of internalized proteins within endo-lysosomes, but cathepsins are also involved in the processing of precursor proteins to biologically active peptides in endosomes of entero-endocrine cells. Cathepsin B, released form intestinal mucosa due to mechanical injury, plays an important role in extracellular matrix damage and the onset of postoperative ileus, an inevitable consequence of abdominal surgery, in that it contributes to disintegration of the basement membrane of the gastrointestinal tract in early post-traumatic phases. Cathepsin B is best known for its critical contribution to enhanced tumor cell invasion and metastasis, including colorectal carcinomas, by degradation of extracellular matrix components Mus musculus ?
-
 ?
N-benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
-
 Mus musculus N-benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
 ?
N-benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
 Mus musculus N-benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
40
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
 assay at Mus musculus