Application | Comment | Organism |
---|---|---|
drug development | peptides containing Ala or Phe at positions 6 are good substrates for the enzyme at both pH 5.0 and 7.4. Those containing Glu, Asp, Lys or Val are not cleaved at all by cathepsin B at pH 7.4 and are poorly hydrolized at pH 5.0. These findings provide new information for the rational design of cathepsin B-activated peptide-containing anticancer drugs | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Bos taurus | - |
- |
lysosome | acidic | Bos taurus | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | P07688 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
spleen | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Z-Phe-Arg-4-methylcoumarin-7-amide + H2O | - |
Bos taurus | Z-Phe-Arg + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cathepsin B | - |
Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4.4 | 5.5 | attack from C-terminus | Bos taurus |
7.4 | - |
endoproteolytic attack | Bos taurus |