Literature summary for 3.4.22.1 extracted from

Wieczerzak, E.; Jankowska, E.; Rodziewicz-Motowidlo, S.; Gieldon, A.; Lagiewka, J.; Grzonka, Z.; Abrahamson, M.; Grubb, A.; Broemme, D.
Novel azapeptide inhibitors of cathepsins B and K. Structural background to increased specificity for cathepsin B (2005), J. Pept. Res., 66 Suppl 1, 1-11.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Z-Arg-Gly-Pro-Agly-Gly-Glu-OMe	-	Homo sapiens
Z-Arg-Leu-His-Agly-Ile-Val-OMe	-	Homo sapiens
Z-Arg-Leu-Phe-Agly-Val-Ala-OMe	-	Homo sapiens
Z-Arg-Leu-Val-Agly-Gly-Asp-OMe	-	Homo sapiens
Z-Arg-Leu-Val-Agly-Gly-Glu-OMe	-	Homo sapiens
Z-Arg-Leu-Val-Agly-Ser-Ala-OMe	-	Homo sapiens
Z-Arg-Nle-Pro-Agly-Gly-Glu-OMe	-	Homo sapiens
Z-Arg-Nle-Val-Agly-Gly-Glu-OMe	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P07858	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzyloxycarbonyl-phenylalanyl-arginyl-7-amido-4-methylcoumarin + H2O	37°C, 1 mM DTT, 1 mM EDTA, pH 6.0	Homo sapiens	Z-Phe-Arg + 7-amino-4-methylcoumarin	-	?

Synonyms

Synonyms	Comment	Organism
cathepsin B	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0000000011	-	Z-Arg-Leu-His-Agly-Ile-Val-OMe	-	Homo sapiens
0.0000000086	-	Z-Arg-Leu-Phe-Agly-Val-Ala-OMe	-	Homo sapiens
0.000000052	-	Z-Arg-Nle-Val-Agly-Gly-Glu-OMe	-	Homo sapiens
0.00000083	-	Z-Arg-Gly-Pro-Agly-Gly-Glu-OMe	-	Homo sapiens
0.000007	-	Z-Arg-Leu-Val-Agly-Gly-Glu-OMe	-	Homo sapiens
0.0000075	-	Z-Arg-Leu-Val-Agly-Gly-Asp-OMe	-	Homo sapiens

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Release 2023.1 (January 2023)